CD163 抗体 (AA 245-274)
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- 抗原 See all CD163 抗体
- CD163
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抗原表位
- AA 245-274
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CD163 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 纯化方法
- Purified
- 免疫原
- A portion of amino acids 245-274 from the human protein was used as the immunogen for this CD163 antibody.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product CD163 Primary Antibody
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- 应用备注
- Titration of the CD163 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Aliquot the CD163 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- 抗原
- CD163
- 别名
- CD163 (CD163 产品)
- 别名
- DMBT1 antibody, CD163 antibody, CD163v2 antibody, CD163v3 antibody, M130 antibody, MM130 antibody, deleted in malignant brain tumors 1 protein-like antibody, CD163 molecule antibody, CD163 antigen antibody, LOC426820 antibody, CD163 antibody, Cd163 antibody
- 背景
- CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
- UniProt
- Q86VB7
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