EIF6 抗体 (AA 66-210)
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- 抗原 See all EIF6 抗体
- EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))
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抗原表位
- AA 66-210
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EIF6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- 纯化方法
- Antigen affinity
- 免疫原
- Amino acids 66-210 of human EIF6/EIF3A were used as the immunogen for the EIF3A antibody.
- 亚型
- IgG
- Top Product
- Discover our top product EIF6 Primary Antibody
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- 应用备注
- Optimal dilution of the EIF3A antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,ICC (Paraffin): 0.5-1 μg/mL
- 限制
- 仅限研究用
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- 缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- 储存条件
- -20 °C
- 储存方法
- After reconstitution, the EIF3A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- 抗原
- EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))
- 别名
- EIF6 / EIF3A (EIF6 产品)
- 背景
- EIF6 (Eukaryotic Translation Initiation Factor 6), also called EIF3A or ITGB4BP, is a human gene. By fluorescence in situ hybridization, Sanvito et al. (1998) mapped the ITGB4BP gene to 20q11.2. Ceci et al. (2003) demonstrated that the ribosomal 60S subunit is activated by release of EIF6. In the cytoplasm, EIF6 is bound to free 60S but not to 80S subunits. Furthermore, EIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C. Gandin et al. (2008) demonstrated that mammalian eIF6 is required for efficient initiation of translation in vivo. Eif6-null mouse embryos were lethal at preimplantation. Heterozygous mice had 50 % reduction of eIF6 levels in all tissues, and showed reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression.
- UniProt
- P56537
- 途径
- Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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