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- 抗原 See all FLT4 抗体
- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FLT4 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人
- 纯化方法
- Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- 免疫原
- Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.
- 克隆位点
- 8C1
- 亚型
- IgG2a
- Top Product
- Discover our top product FLT4 Primary Antibody
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anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 25-259) antibody
FLT4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 1174-1363) antibodyFLT4 适用: 人 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 1-439) antibodyFLT4 适用: 人 WB, FACS, IHC (p) 宿主: 小鼠 Monoclonal 818CT12-1-1 unconjugated
anti-Fms-Related Tyrosine Kinase 4 (FLT4) antibodyFLT4 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 818CT12-1-1 unconjugated
anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 901-1000) antibodyFLT4 适用: 人, 小鼠, Cow ELISA, FACS, IHC (p), IF (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 720-760) antibodyFLT4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 34-133) antibodyFLT4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5B5 unconjugated
anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 640-700) antibodyFLT4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 1112-1329) antibodyFLT4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related Tyrosine Kinase 4 (FLT4) antibodyFLT4 适用: 人, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IHC-P 1:200-400
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
- 别名
- VEGFR3 (FLT4 产品)
- 别名
- FLT41 antibody, LMPH1A antibody, PCL antibody, VEGFR3 antibody, AI323512 antibody, Chy antibody, Flt-4 antibody, VEGFR-3 antibody, Vegfr3 antibody, cb1059 antibody, fms related tyrosine kinase 4 antibody, FMS-like tyrosine kinase 4 antibody, fms-related tyrosine kinase 4 antibody, FLT4 antibody, Flt4 antibody, flt4 antibody
- 背景
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Synonyms: PCL, FLT-4, FLT41, LMPH1A, VEGFR3, VEGFR-3, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, FLT4
Background: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
- 基因ID
- 2324
- UniProt
- P35916
- 途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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