USP5 抗体
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- 抗原 See all USP5 抗体
- USP5 (Ubiquitin Specific Peptidase 5 (USP5))
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适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This USP5 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
- 免疫原
- This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.
- 克隆位点
- 13C4
- 亚型
- IgG1
- Top Product
- Discover our top product USP5 Primary Antibody
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- 应用备注
- WB 1:300-5000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- USP5 (Ubiquitin Specific Peptidase 5 (USP5))
- 别名
- USP5 (USP5 产品)
- 别名
- ISOT antibody, AA407472 antibody, ISOT-1 antibody, Ucht antibody, ubiquitin specific peptidase 5 antibody, ubiquitin carboxyl-terminal hydrolase 5 antibody, ubiquitin carboxyl-terminal hydrolase 5, putative antibody, ubiquitin specific protease 5 antibody, ubiquitin specific peptidase 5 (isopeptidase T) antibody, USP5 antibody, CNH02890 antibody, EHI_049940 antibody, CC1G_12961 antibody, MCYG_01862 antibody, CGB_L3600C antibody, PY00546 antibody, Usp5 antibody
- 背景
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Synonyms: ISOT, Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5, USP5, USP 5, USP-5
Background: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
- 基因ID
- 8078
- UniProt
- P45974
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