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SLC26A6 抗体 (AA 431-500)

SLC26A6 适用: Pig, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN4914082
发货至: 中国
  • 抗原 See all SLC26A6 抗体
    SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))
    抗原表位
    • 14
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 431-500
    适用
    • 21
    • 14
    • 14
    • 2
    • 1
    Pig, 大鼠
    宿主
    • 31
    • 3
    • 2
    克隆类型
    • 36
    多克隆
    标记
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLC26A6 antibody is un-conjugated
    应用范围
    • 25
    • 12
    • 12
    • 9
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    交叉反应
    Pig, 大鼠
    预测反应
    Mouse
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human SLC26A6
    亚型
    IgG
    Top Product
    Discover our top product SLC26A6 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))
    别名
    SLC26A6 (SLC26A6 产品)
    别名
    B930010B04Rik antibody, CFEX antibody, Pat1 antibody, MGC81960 antibody, SLC26A6 antibody, slc26a6 antibody, MGC145603 antibody, si:dkey-20d21.8 antibody, solute carrier family 26 member 6 antibody, solute carrier family 26, member 6 antibody, solute carrier family 26 member 6 S homeolog antibody, anion exchanger SLC26A6 antibody, SLC26A6 antibody, Slc26a6 antibody, slc26a6.S antibody, slc26a6 antibody
    背景

    Synonyms: Solute carrier family 26 member 6, Anion exchange transporter, Pendrin-like protein 1, Pendrin-L1, SLC26A6

    Background: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney.

    基因ID
    65010
    UniProt
    Q9BXS9
    途径
    Dicarboxylic Acid Transport
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