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RNF20 抗体

RNF20 适用: 人 WB 宿主: 小鼠 Monoclonal 4C6 unconjugated
产品编号 ABIN4913698
发货至: 中国
  • 抗原 See all RNF20 抗体
    RNF20 (Ring Finger Protein 20 (RNF20))
    适用
    • 63
    • 35
    • 21
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    宿主
    • 58
    • 5
    小鼠
    克隆类型
    • 51
    • 12
    单克隆
    标记
    • 28
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This RNF20 antibody is un-conjugated
    应用范围
    • 43
    • 18
    • 13
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    交叉反应
    纯化方法
    Purified by Protein G.
    免疫原
    This RNF20 antibody is generated from a mouse immunized with a recombinant protein of human RNF20.
    克隆位点
    4C6
    亚型
    IgG1
    Top Product
    Discover our top product RNF20 Primary Antibody
  • 应用备注
    WB 1:300-5000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    RNF20 (Ring Finger Protein 20 (RNF20))
    别名
    RNF20 (RNF20 产品)
    背景

    Synonyms: BRE1, BRE1A, hBRE1, E3 ubiquitin-protein ligase BRE1A, BRE1-A, RING finger protein 20, RNF20

    Background: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

    基因ID
    56254
    UniProt
    Q5VTR2
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