RAD50 抗体 (AA 817-872)
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- 抗原 See all RAD50 抗体
- RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))
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抗原表位
- AA 817-872
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RAD50 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠
- 预测反应
- Rat,Cow,Sheep,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human RAD50
- 亚型
- IgG
- Top Product
- Discover our top product RAD50 Primary Antibody
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anti-RAD50 Homolog (S. Cerevisiae) (RAD50) antibody
RAD50 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 228-359) antibodyRAD50 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 3D2G10 unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 1-100) antibodyRAD50 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (Internal Region) antibodyRAD50 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 228-359) antibodyRAD50 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5A8E5 unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 1-234) antibodyRAD50 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) antibodyRAD50 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 700-750) antibodyRAD50 适用: 人, 小鼠, Cow, 兔, 犬 IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 631-793) antibodyRAD50 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 400-595) antibodyRAD50 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))
- 别名
- RAD50 (RAD50 产品)
- 背景
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Synonyms: DNA repair protein RAD50, RAD50, hRAD50
Background: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).
- 基因ID
- 10111
- UniProt
- Q92878
- 途径
- DNA Damage Repair, Protein targeting to Nucleus
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