MASTL 抗体
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- 抗原 See all MASTL 抗体
- MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MASTL antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 人
- 纯化方法
- Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
- 免疫原
- This MASTL monoclonal antibody is generated from mouse immunized with MASTL recombinant protein.
- 克隆位点
- 5C3
- 亚型
- IgG1
- Top Product
- Discover our top product MASTL Primary Antibody
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- 应用备注
- WB 1:300-5000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))
- 别名
- MASTL (MASTL 产品)
- 别名
- GW antibody, GWL antibody, MAST-L antibody, im:7149025 antibody, wu:fa02a12 antibody, zgc:100990 antibody, MASTL antibody, GREATWALL antibody, RP11-85G18.2 antibody, THC2 antibody, hGWL antibody, 2700091H24Rik antibody, C88295 antibody, greatwall antibody, thc2 antibody, microtubule associated serine/threonine kinase-like antibody, microtubule associated serine/threonine kinase like antibody, serine/threonine-protein kinase greatwall antibody, microtubule associated serine/threonine kinase like L homeolog antibody, mastl antibody, MASTL antibody, LOC100541707 antibody, Mastl antibody, mastl.L antibody
- 背景
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Synonyms: GW, GWL, THC2, MAST-L, GREATWALL, Serine/threonine-protein kinase greatwall, hGWL, Microtubule-associated serine/threonine-protein kinase-like, MASTL
Background: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro, however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
- 基因ID
- 84930
- UniProt
- Q96GX5
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