CSF1R 抗体
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- 抗原 See all CSF1R 抗体
- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CSF1R antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人
- 纯化方法
- Purified by Protein G.
- 免疫原
- This CSF1R antibody is generated from a mouse immunized with a recombinant protein.
- 克隆位点
- 6C7
- 亚型
- IgG1
- Top Product
- Discover our top product CSF1R Primary Antibody
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anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 344-497) antibody
CSF1R 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 6B9B9 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 344-497) antibodyCSF1R 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6B9H2 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (pTyr723) antibodyCSF1R 适用: 人, 犬 WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 940-971) antibodyCSF1R 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (Tyr809) antibodyCSF1R 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 21-120) antibodyCSF1R 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3G12 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-152) antibodyCSF1R 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4C9G2 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 895-923), (C-Term) antibodyCSF1R 适用: 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB34462 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 895-923) antibodyCSF1R 适用: 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 201-300) antibodyCSF1R 适用: 人 ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
- 别名
- CSF1R (CSF1R 产品)
- 背景
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Synonyms: FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R, Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, CSF-1-R, Proto-oncogene c-Fms, CSF1R
Background: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1.
- 基因ID
- 1436
- UniProt
- P07333
- 途径
- RTK signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
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