c-Rel 抗体
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- 抗原 See all c-Rel 抗体
- c-Rel (REL proto-oncogene (c-Rel))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This c-Rel antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
- 免疫原
- This REL monoclonal antibody is generated from mouse immunized with REL recombinant protein.
- 克隆位点
- 8C2
- 亚型
- IgG2b
- Top Product
- Discover our top product c-Rel Primary Antibody
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- 应用备注
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WB 1:300-5000
IF() - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- c-Rel (REL proto-oncogene (c-Rel))
- 别名
- C-rel (c-Rel 产品)
- 别名
- C-Rel antibody, c-Rel antibody, NFkB antibody, c-rel antibody, zgc:100833 antibody, Xrel2 antibody, Xrel3 antibody, rel antibody, rel-A antibody, rel2 antibody, rel3 antibody, v-rel antibody, xrel antibody, REL proto-oncogene, NF-kB subunit antibody, reticuloendotheliosis oncogene antibody, RELA proto-oncogene, NF-kB subunit antibody, v-rel avian reticuloendotheliosis viral oncogene homolog antibody, v-rel avian reticuloendotheliosis viral oncogene homolog L homeolog antibody, ribonuclease A family member 2 pseudogene antibody, REL antibody, Rel antibody, Rela antibody, rel antibody, rel.L antibody, ECRP antibody
- 背景
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Synonyms: C-Rel, Proto-oncogene c-Rel, REL
Background: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
- 基因ID
- 5966
- UniProt
- Q04864
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