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CDCP1 抗体 (AA 582-667)

CDCP1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN4886532
发货至: 中国
  • 抗原 See all CDCP1 抗体
    CDCP1 (CUB Domain Containing Protein 1 (CDCP1))
    抗原表位
    • 12
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 582-667
    适用
    • 69
    • 24
    • 13
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 42
    • 26
    • 2
    • 2
    • 1
    克隆类型
    • 46
    • 26
    多克隆
    标记
    • 39
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    This CDCP1 antibody is un-conjugated
    应用范围
    • 43
    • 31
    • 11
    • 9
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    原理
    Rabbit IgG polyclonal antibody for CUB domain-containing protein 1(CDCP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for CUB domain-containing protein 1(CDCP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: CUB domain containing protein 1
    Protein Name: CUB domain-containing protein 1
    纯化方法
    Immunogen affinity purified.
    免疫原
    E. coli-derived human CDCP1 recombinant protein (Position: R582-T667). Human CDCP1 shares 84.5% amino acid (aa) sequence identity with mouse CDCP1.
    亚型
    IgG
    Top Product
    Discover our top product CDCP1 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • 抗原
    CDCP1 (CUB Domain Containing Protein 1 (CDCP1))
    别名
    CDCP1 (CDCP1 产品)
    别名
    CD318 antibody, SIMA135 antibody, TRASK antibody, 9030022E12Rik antibody, AA409659 antibody, E030027H19Rik antibody, RGD1305578 antibody, zgc:113071 antibody, CUB domain containing protein 1 antibody, CUB domain containing protein 1a antibody, CDCP1 antibody, Cdcp1 antibody, cdcp1a antibody
    背景
    CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). CDCP1/Trask is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. The tyrosine phosphorylation of Trask is tightly regulated and reciprocally linked with the state of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion.

    Synonyms: CD 318 | CD318 | CD318 antigen | CDCP 1 | CDCP1 | SIMA 135 | SIMA135 | TRASK | Q9H5V8
    基因ID
    64866
    UniProt
    Q9H5V8
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