电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

Methotrexate 抗体

MTX EIA 宿主: 绵羊 Polyclonal unconjugated
产品编号 ABIN487772
发货至: 中国
  • 抗原 See all Methotrexate (MTX) 抗体
    Methotrexate (MTX)
    适用
    请咨询
    宿主
    • 3
    绵羊
    克隆类型
    • 2
    多克隆
    标记
    • 3
    This Methotrexate antibody is un-conjugated
    应用范围
    • 3
    • 1
    • 1
    Enzyme Immunoassay (EIA)
    纯化方法
    Ig Fraction
    免疫原
    Methotrexate -BSA
    亚型
    IgG
    Top Product
    Discover our top product MTX Primary Antibody
  • 应用备注
    ELISA: 2.5 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    7.74 mg/mL (U.V.abs at 280nm)
    缓冲液
    20 mM Phosphate, 150 mM Sodium Chloride, pH 7.2 containing 0.09 % Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
  • 抗原
    Methotrexate (MTX)
    别名
    Methotrexate (MTX 产品)
    物质类
    Amino Acid
    背景
    Methotrexate (rINN) abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases and as an abortifacient in the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. The affinity of methotrexate for DHFR is about one thousand-fold that of folate for DHFR. Methotrexate acts specifically during DNA and RNA synthesis, and thus it is cytotoxic during the S-phase of the cell cycle. Logically, it therefore has a greater toxic effect on rapidly dividing cells which replicate their DNA more frequently, and thus inhibits the growth and proliferation of these non-cancerous cells. Lower doses of methotrexate have been shown to be very effective for the management of rheumatoid arthritis, Crohn's disease, and psoriasis.Synonyms: 4-amino-10-methylpteroyl-L-glutamic acid
You are here:
客服