The mouse monoclonal antibody IP26 recognizes a monomorphic extracellular determinant of TCR alpha/beta, the dominant subtype of T cell receptor expressed in human peripheral blood.
Flow cytometry: Recommended dilution: 2-4 μg/mL, positive control: human peripheral blood T cells.
限制
仅限研究用
浓度
1 mg/mL
缓冲液
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Do not freeze.
储存条件
4 °C
储存方法
Store at 2-8°C. Do not freeze.
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Ortonne, Huet, Gaudez, Marie-Cardine, Schiavon, Bagot, Musette, Bensussan: "Significance of circulating T-cell clones in Sezary syndrome." in: Blood, Vol. 107, Issue 10, pp. 4030-8, (2006) (PubMed).
Huet, Bagot, Loyaux, Capdevielle, Conraux, Ferrara, Bensussan, Marie-Cardine: "SC5 mAb represents a unique tool for the detection of extracellular vimentin as a specific marker of Sezary cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 1, pp. 652-9, (2005) (PubMed).
The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.,TCRA/B