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L-Selectin 抗体 (FITC)

SELL 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal Mel-14 FITC
产品编号 ABIN457350
发货至: 中国
  • 抗原 See all L-Selectin (SELL) 抗体
    L-Selectin (SELL) (Selectin L (SELL))
    适用
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    小鼠
    宿主
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    大鼠
    克隆类型
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    单克隆
    标记
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    This L-Selectin antibody is conjugated to FITC
    应用范围
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    Flow Cytometry (FACS)
    特异性
    The rat monoclonal antibody MEL-14 reacts with an extracellular epitope of murine CD62L (L-selectin), a 75 kDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes, it is also present on a subset of NK cells and certain hematopoietic malignant cells.
    交叉反应 (详细)
    Mouse
    纯化方法
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    免疫原
    C3H/eb mouse B cell lymphoma 38C-13
    克隆位点
    Mel-14
    亚型
    IgG2a
    Top Product
    Discover our top product SELL Primary Antibody
  • 应用备注
    Flow cytometry: Recommended dilution: 1 μg/mL.
    说明

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.

    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    Avoid prolonged exposure to light.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Xu, Manivannan, Crane, Dawson, Liversidge: "Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation." in: Blood, Vol. 112, Issue 4, pp. 1166-74, (2008) (PubMed).

    Pop, Wong, He, Wang, Wallet, Goudy, Tisch: "The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice." in: Diabetes, Vol. 56, Issue 5, pp. 1395-402, (2007) (PubMed).

    Richards, Longhi, Wright, Gallimore, Ager: "CD62L (L-selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 1, pp. 198-206, (2007) (PubMed).

    Chen, Cui, Sempowski, Liu, Chao: "Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease." in: Blood, Vol. 103, Issue 4, pp. 1534-41, (2004) (PubMed).

    Chin, Miller, Graham, Parviz, Zacur, Patel, Duong, Bear: "Bryostatin 1/ionomycin (B/I) ex vivo stimulation preferentially activates L-selectinlow tumor-sensitized lymphocytes." in: International immunology, Vol. 16, Issue 9, pp. 1283-94, (2004) (PubMed).

    Friedline, Wong, Steeber, Tedder, Tisch: "L-selectin is not required for T cell-mediated autoimmune diabetes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 6, pp. 2659-66, (2002) (PubMed).

    Mannering, Cheers: "Interleukin-2 and loss of immunity in experimental Mycobacterium avium infection." in: Infection and immunity, Vol. 70, Issue 1, pp. 27-35, (2001) (PubMed).

    ten Bruggencate, Hillyer, Woodward: "The proportion of CD45RA(+)CD62L(+) (quiescent-phenotype) T cells within the CD8(+) subset increases in advanced weight loss in the protein- or energy-deficient weanling mouse." in: The Journal of nutrition, Vol. 131, Issue 12, pp. 3266-9, (2001) (PubMed).

    Brawand, Cerottini, MacDonald: "Hierarchal utilization of different T-cell receptor Vbeta gene segments in the CD8(+)-T-cell response to an immunodominant Moloney leukemia virus-encoded epitope in vivo." in: Journal of virology, Vol. 73, Issue 11, pp. 9161-9, (1999) (PubMed).

  • 抗原
    L-Selectin (SELL) (Selectin L (SELL))
    别名
    CD62L / L-Selectin (SELL 产品)
    别名
    CD62L antibody, LAM1 antibody, LECAM1 antibody, LEU8 antibody, LNHR antibody, LSEL antibody, LYAM1 antibody, PLNHR antibody, TQ1 antibody, A.11 antibody, L-selectin antibody, LECAM-1 antibody, SELE antibody, AI528707 antibody, Lnhr antibody, Ly-22 antibody, Ly-m22 antibody, Lyam-1 antibody, Lyam1 antibody, selectin L antibody, selectin, lymphocyte antibody, SELL antibody, Sell antibody
    背景
    Selectin L,CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1).,L-selectin, Lsel, Sell, Lam1, Lecam, Leu8, Lnhr, Lyam1, Plnhr
    基因ID
    20343
    UniProt
    Q3TCF3
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