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BRISC and BRCA1 A Complex Member 1 (BABAM1) (Middle Region) 抗体

BABAM1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN453692
发货至: 中国
  • 抗原 See all BRISC and BRCA1 A Complex Member 1 (BABAM1) 抗体
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    抗原表位
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    Middle Region
    适用
    • 26
    • 3
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    • 1
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    宿主
    • 21
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    • 1
    克隆类型
    • 24
    • 2
    多克隆
    标记
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    非结合性
    应用范围
    • 23
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody recognizes MERIT40/HSPC142 (Center).
    纯化方法
    Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    KLH conjugated synthetic peptide selected from the Center region of Human HSPC142
    Top Product
    Discover our top product BABAM1 Primary Antibody
  • 应用备注
    ELISA: 1/1,000. Western blotting: 1/50-1/100. Immunohistochemistry: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    别名
    MERIT40 (BABAM1 产品)
    别名
    merit40 antibody, nba1 antibody, zgc:100909 antibody, c19orf62 antibody, C19orf62 antibody, MERIT40 antibody, NBA1 antibody, C7H19orf62 antibody, 5430437P03Rik antibody, Merit40 antibody, BRISC and BRCA1 A complex member 1 antibody, BRISC and BRCA1 A complex member 1 L homeolog antibody, babam1 antibody, BABAM1 antibody, babam1.L antibody, Babam1 antibody
    背景
    Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.Synonyms: BRCA1-A complex subunit MERIT40, C19orf62, HSPC142, Mediator of RAP80 interactions and targeting subunit of 40 kDa, NBA1, New component of the BRCA1-A complex
    基因ID
    29086
    NCBI登录号
    NP_001028721
    UniProt
    Q9NWV8
    途径
    Positive Regulation of Response to DNA Damage Stimulus
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