EGF
适用: 小鼠
WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro)
宿主: 兔
Polyclonal
unconjugated
应用备注
ELISA. Matched Pair: Clone S-134 Cat. No. : DM1012Clone S-146 Cat. No. : ABIN452469 Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
溶解方式
Restore with Double distillated water to adjust the final concentration to 1.0 mg/mL.
浓度
1.0 mg/mL
缓冲液
0.01 M PBS, pH 7.2 without preservatives
储存液
Without preservative
储存条件
-20 °C
储存方法
Store the antibody at -20 °C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Epidermal growth factor (EGF) has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. EGF exerts its actions by binding to the EGFR, a 170 kDa protein. Epidermal growth factor (EGF) is a key growth factor regulating cell survival. Through its binding to cell surface receptors, EGF activates an extensive network of signal transduction pathways that include activation of the PI3K/AKT, RAS/ERK and JAK/STAT pathways. Because of its key role in driving the proliferation of cells, EGFR is a target of several anti-cancer drugs currently in development.Synonyms: Epidermal growth factor, HOMG4, Pro-epidermal growth factor, URG, Urogastrone