PFKFB4 抗体 (AA 266-296)
(5 references)-
- 抗原 See all PFKFB4 抗体
- PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))
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抗原表位
- AA 266-296
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PFKFB4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 预测反应
- Pr
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This PFKFB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-296 amino acids from the Central region of human PFKFB4.
- 克隆位点
- RB04059
- 亚型
- IgG
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anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) antibody
PFKFB4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) antibodyPFKFB4 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 274-303) antibodyPFKFB4 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-368) antibodyPFKFB4 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (N-Term) antibodyPFKFB4 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 斑马鱼, Cow, Pig, Bat, Hamster, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (N-Term) antibodyPFKFB4 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (N-Term) antibodyPFKFB4 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 斑马鱼, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-296) antibodyPFKFB4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. IHC-P: 1:100. IHC-P: 1:250
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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: "6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells." in: Oncogene, Vol. 36, Issue 23, pp. 3287-3299, (2017) (PubMed).
: "Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway." in: American journal of physiology. Endocrinology and metabolism, Vol. 303, Issue 6, pp. E695-707, (2012) (PubMed).
: "Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival." in: Cancer discovery, Vol. 2, Issue 4, pp. 328-43, (2012) (PubMed).
: "Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases." in: The Journal of biological chemistry, Vol. 284, Issue 36, pp. 24223-32, (2009) (PubMed).
: "Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death." in: Cancer research, Vol. 65, Issue 3, pp. 999-1006, (2005) (PubMed).
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: "6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells." in: Oncogene, Vol. 36, Issue 23, pp. 3287-3299, (2017) (PubMed).
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- 抗原
- PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))
- 别名
- PFKFB4 (PFKFB4 产品)
- 别名
- MGC69186 antibody, MGC81068 antibody, PFKFB4 antibody, zgc:123288 antibody, C230090D14 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 S homeolog antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a antibody, pfkfb4 antibody, pfkfb4.S antibody, PFKFB4 antibody, pfkfb4a antibody, f264 antibody, Pfkfb4 antibody
- 背景
- Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
- 分子量
- 54040
- 基因ID
- 5210
- NCBI登录号
- NP_004558
- UniProt
- Q16877
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