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PFKL 抗体 (C-Term)

Name: PFKL 抗体 (C-Term)
SKU: ABIN392745
Availability: OutOfStock

PFKL 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB03903 unconjugated

The anti-PFKL Pab (ABIN392745 and ABIN2842201) is used in Western blot to detect PFKL in HepG2 cell lysate. (PFKL 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (PFKL 抗体 (C-Term))

IHC (p)

2 images

(1 reference)

产品编号 ABIN392745

发货至: 中国

Datasheet as PDF

抗原 See all PFKL 抗体

PFKL (Phosphofructokinase, Liver (PFKL))
抗原表位
7

6

4

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 669-699, C-Term
适用
43

25

18

4

3

2

2

1

1

1

1

1

1
人, 小鼠
宿主
40

5
兔
Compatible Secondaries
克隆类型
42

3
多克隆
标记
29

3

3

2

1

1

1

1

1

1

1

1
This PFKL antibody is un-conjugated
应用范围
33

18

18

6

4

4

3

3

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This PFKL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 669-699 amino acids from the C-terminal region of human PFKL.

克隆位点

RB03903

亚型

Ig Fraction

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PFKL 适用: 人, 小鼠 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Phosphofructokinase, Liver (PFKL) (AA 229-479) antibody
PFKL 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Phosphofructokinase, Liver (PFKL) (AA 700-780) antibody
PFKL 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Phosphofructokinase, Liver (PFKL) (Middle Region) antibody
PFKL 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 绵羊, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

anti-Phosphofructokinase, Liver (PFKL) (C-Term) antibody
PFKL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphofructokinase, Liver (PFKL) (AA 371-399) antibody
PFKL 适用: 人 WB 宿主: 兔 Polyclonal RB6851 unconjugated

anti-Phosphofructokinase, Liver (PFKL) (C-Term) antibody
PFKL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphofructokinase, Liver (PFKL) (AA 441-540) antibody
PFKL 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A9 unconjugated

anti-Phosphofructokinase, Liver (PFKL) (C-Term) antibody
PFKL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Phosphofructokinase, Liver (PFKL) (AA 1-827) antibody
PFKL 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Mikawa, Maruyama, Okamoto, Nakagama, Lleonart, Tsusaka, Hori, Murakami, Izumi, Takaori-Kondo, Yokode, Peters, Beach, Kondoh: "Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2." in: The Journal of cell biology, Vol. 204, Issue 5, pp. 729-45, (2014) (PubMed).
抗原

PFKL (Phosphofructokinase, Liver (PFKL))

别名

PFKL (PFKL 产品)

别名

PFK-B antibody, AA407869 antibody, phosphofructokinase, liver type antibody, phosphofructokinase, liver, B-type antibody, PFKL antibody, Pfkl antibody

背景

Phosphofructokinase (PFK), a major regulatory enzyme in all cells of the body, catalyzes the metabolism of sugar, and thereby is pivotal in the production of energy to maintain normal cell function. In human there are three structural loci controlling PFK: M (muscle), L (liver), and P (platelet) type subunits, which are variably expressed in different tissues, human diploid fibroblasts and leukocytes express all three genes. PFK, a tetramer formed by the random association of the products of two separate gene loci to form the five possible tetramers. PFKs of muscle and liver are homotetramers of the M and L subunits, respectively. Red cells have all five isozymes: M4, M3L, M2L2, ML3, and L4. PFK is an allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. PFK catalyzes the key controlling step of glycolytic pathway. PFK deficiency can present as mild to life-threatening episodic illness. A hallmark sign of this disease is intermittent dark urine, with the color of the urine ranging from orange to dark coffee-brown, which commonly develops following strenuous exercise. The mean red cell PFK is elevated in persons with Down syndrome.

分子量

85018

基因ID

5211

NCBI登录号

NP_002617

UniProt

P17858

途径

Negative Regulation of Hormone Secretion, Warburg Effect