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GSK3 alpha 抗体 (C-Term)

Name: GSK3 alpha 抗体 (C-Term)
SKU: ABIN392711
Availability: OutOfStock

GSK3a 适用: 人 WB 宿主: 兔 Polyclonal RB3819-3820 unconjugated

Anti-GSK3A Antibody at 1:1000 dilution + A549 whole cell lysate Lysates/proteins at 20 μg per lane. (GSK3 alpha 抗体 (C-Term))

1 image

(1 reference)

产品编号 ABIN392711

发货至: 中国

Datasheet as PDF

抗原 See all GSK3 alpha (GSK3a) 抗体

GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
抗原表位
31

15

13

12

9

7

6

5

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 448-478, C-Term
适用
95

81

64

5

5

3

3

2

2
人
宿主
109

20

2
兔
Compatible Secondaries
克隆类型
109

24
多克隆
标记
74

10

8

7

4

4

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
This GSK3 alpha antibody is un-conjugated
应用范围
105

61

56

18

18

14

13

13

7

3

3

3

2
Western Blotting (WB)

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This GSK3 alpha (GSK3A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 448-478 amino acids from the C-terminal region of human GSK3 alpha (GSK3A).

克隆位点

RB3819-3820

亚型

Ig Fraction

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GSK3a 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (pSer21) antibody
GSK3a 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) antibody
KO Validated GSK3a 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 122-406) antibody
GSK3a 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 76-105), (N-Term) antibody
GSK3a 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3817-3818 unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 409-483) antibody
GSK3a 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) antibody
GSK3a 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 9D5G1 unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) antibody
GSK3a 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 6G2F1 unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody
GSK3a 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 36-118) antibody
GSK3a 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.

有效期

6 months
Chang, Nam, Kook, Kim, Liu, Yao, Jung, Lemos, Seo, Park, Gim, Hong, Huh, Kim, Tan, Liu, Powis, Park, Liang, Kim: "HNF4? is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer." in: Gut, (2014) (PubMed).
抗原

GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

别名

GSK3 alpha (GSK3A) (GSK3a 产品)

别名

2700086H06Rik antibody, GSK3A antibody, GSK-3[a] antibody, GSK-3[b] antibody, GSK3 antibody, gsk3a antibody, xgsk3 antibody, glycogen synthase kinase 3 alpha antibody, glycogen synthase kinase 3 alpha b antibody, glycogen synthase kinase 3 alpha S homeolog antibody, GSK3A antibody, Gsk3a antibody, gsk3a antibody, gsk3ab antibody, gsk3a.S antibody, Bm1_31380 antibody

背景

Glycogen synthase kinase 3-alpha (GSK3A)is a multifunctional protein serine kinase implicated in the control of several regulatory proteins including glycogen synthase and transcription factors. It also plays a role in the WNT and PI3K signaling pathways.1 Under resting conditions GSK3A and its homologs are highly phosphorylated at tyr279 in the phosphorylation loop.2 Constitutive phosphorylation of this tyrosine is important for kinase activity. Dephosphorylation of tyr279 after mitogen activation is accompanied by kinase inactivation. PKA as well as PI3K-activated PKB inactivate GSK3A by phosphorylation at ser21.3 Lysophosphatidic acid primarily utilizes a PKC-dependent pathway to modulate GSK3 and certain growth factors (e.g., PDGFB), which control GSK3 mainly through PIK3-PKB, are able to regulate GSK3 through an alternative, redundant phospholipase-C-gamma-PKC pathway.4 Alzheimer disease (AD) is associated with increased production and aggregation of amyloid-beta-40 and -42 peptides into plaques. GSK3A is required for maximal production of the beta-amyloid-40 and -42 peptides generated from the amyloid precursor protein (APP) by presenilin (PSEN1)-dependent gamma-secretase cleavage.5 In vitro, lithium, a GSK3A inhibitor, blocked the production of the beta-amyloid peptides by interfering with the gamma-secretase step. In mice expressing familial AD-associated mutations in APP and PSEN1, lithium reduced the levels of beta-amyloid peptides GSK3A also phosphorylates the tau protein (MAPT), the principal component of neurofibrillary tangles in AD, and suggested that inhibition of GSK3A may offer a new therapeutic approach to AD.

分子量

50981

NCBI登录号

NP_063937

UniProt

P49840

途径

PI3K-Akt Signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effect