PACSIN2 抗体 (C-Term)
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- 抗原 See all PACSIN2 抗体
- PACSIN2 (Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2))
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抗原表位
- AA 342-371, C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PACSIN2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This PACSIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-371 amino acids from the C-terminal region of human PACSIN2.
- 克隆位点
- RB3584
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PACSIN2 Primary Antibody
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- 应用备注
- WB: 1:1000. IHC-P: 1:25. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal." in: Molecular biology of the cell, Vol. 28, Issue 22, pp. 3095-3111, (2018) (PubMed).
: "Characterization of a caveolin-1 mutation associated with both pulmonary arterial hypertension and congenital generalized lipodystrophy." in: Traffic (Copenhagen, Denmark), Vol. 17, Issue 12, pp. 1297-1312, (2017) (PubMed).
: "Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis." in: PLoS pathogens, Vol. 12, Issue 12, pp. e1006070, (2017) (PubMed).
: "Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development." in: Scientific reports, Vol. 6, pp. 20727, (2016) (PubMed).
: "EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF ..." in: The Journal of biological chemistry, Vol. 291, Issue 26, pp. 13465-78, (2016) (PubMed).
: "Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes." in: The Journal of biological chemistry, Vol. 288, Issue 42, pp. 30172-80, (2013) (PubMed).
: "Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis." in: Molecular biology of the cell, Vol. 24, Issue 11, pp. 1776-90, S1-15, (2013) (PubMed).
: "The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization." in: The Journal of biological chemistry, Vol. 287, Issue 52, pp. 43438-53, (2012) (PubMed).
: "Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis." in: Journal of cell science, Vol. 124, Issue Pt 16, pp. 2777-85, (2011) (PubMed).
: "The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration." in: Journal of cell science, Vol. 124, Issue Pt 14, pp. 2375-88, (2011) (PubMed).
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A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal." in: Molecular biology of the cell, Vol. 28, Issue 22, pp. 3095-3111, (2018) (PubMed).
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- 抗原
- PACSIN2 (Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2))
- 别名
- PACSIN2 (PACSIN2 产品)
- 别名
- zgc:77519 antibody, PACSIN2 antibody, DKFZp459J1025 antibody, SDPII antibody, AI197433 antibody, sdpii antibody, SdpII antibody, protein kinase C and casein kinase substrate in neurons 2 antibody, protein kinase C and casein kinase substrate in neurons 2 S homeolog antibody, pacsin2 antibody, PACSIN2 antibody, Pacsin2 antibody, pacsin2.S antibody
- 背景
- PACSIN may play a role in vesicle formation and transport. This protein homo- and hetero-aggregates with other PACSINs. It also binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). The protein exhibits a cvesicle-like cytoplasmic distribution and is ubiquitously expressed. PACSIN is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). The protein contains 1 FCH domain and 1 SH3 domain.
- 分子量
- 55739
- 基因ID
- 11252
- NCBI登录号
- NP_001171899, NP_001171900, NP_009160
- UniProt
- Q9UNF0
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