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PIK3R3 抗体 (C-Term)

PIK3R3 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB1719 unconjugated
产品编号 ABIN392576
发货至: 中国
  • 抗原 See all PIK3R3 抗体
    PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3))
    抗原表位
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 316-346, C-Term
    适用
    • 45
    • 34
    • 18
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 40
    • 4
    • 1
    • 1
    克隆类型
    • 36
    • 10
    多克隆
    标记
    • 27
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This PIK3R3 antibody is un-conjugated
    应用范围
    • 29
    • 16
    • 14
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This PIK3R3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-346 amino acids from the C-terminal region of human PIK3R3.
    克隆位点
    RB1719
    亚型
    Ig Fraction
    Top Product
    Discover our top product PIK3R3 Primary Antibody
  • 应用备注
    IF: 1:100. WB: 1:1000. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Yang, Cheng, Zhou, Zhu, Hu, Yang: "Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K/mTOR in Human Osteosarcoma." in: International journal of molecular sciences, Vol. 16, Issue 12, pp. 28635-46, (2016) (PubMed).

    Wang, Yang, Jin, Deng, Luo, Hu, Wang: "TGF-? regulates the proliferation of lung adenocarcinoma cells by inhibiting PIK3R3 expression." in: Molecular carcinogenesis, (2014) (PubMed).

    Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." in: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).

    Zhang, Huang, Yang, Greshock, Liang, Hasegawa, Giannakakis, Poulos, OBrien-Jenkins, Katsaros, Butzow, Weber, Coukos: "Integrative genomic analysis of phosphatidylinositol 3'-kinase family identifies PIK3R3 as a potential therapeutic target in epithelial ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 18 Pt 1, pp. 5314-21, (2007) (PubMed).

  • 抗原
    PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3))
    别名
    PIK3R3 (PIK3R3 产品)
    别名
    AA414954 antibody, p55pik antibody, p55 antibody, p55-GAMMA antibody, pik3r3 antibody, zgc:55564 antibody, zgc:85710 antibody, phosphoinositide-3-kinase regulatory subunit 3 antibody, phosphoinositide-3-kinase, regulatory subunit 3 (gamma) antibody, phosphoinositide-3-kinase, regulatory subunit 3b (gamma) antibody, PIK3R3 antibody, Pik3r3 antibody, pik3r3b antibody
    背景
    PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. It is a component of a heterodimer of p110 (catalytic) and p55 (regulatory) subunits. The protein is expressed at highest levels in brain and testis. Lower levels are detected in adipose tissue, kidney, heart, lung and skeletal muscle. The protein contains 2 SH2 domains.
    分子量
    54448
    基因ID
    8503
    NCBI登录号
    NP_001107644, NP_003620
    UniProt
    Q92569
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