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MAP3K8 抗体 (C-Term)

MAP3K8 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB03467 unconjugated
产品编号 ABIN392472
发货至: 中国
  • 抗原 See all MAP3K8 抗体
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    抗原表位
    • 19
    • 12
    • 9
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 368-397, C-Term
    适用
    • 86
    • 41
    • 39
    • 7
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    宿主
    • 85
    • 1
    克隆类型
    • 85
    • 1
    多克隆
    标记
    • 37
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAP3K8 antibody is un-conjugated
    应用范围
    • 54
    • 40
    • 29
    • 16
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    M, Rat
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This COT (MAP3K8/MEKK8) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-397 amino acids from the C-terminal region of human COT (MAP3K8/MEKK8).
    克隆位点
    RB03467
    亚型
    Ig Fraction
    Top Product
    Discover our top product MAP3K8 Primary Antibody
  • 应用备注
    WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    别名
    COT (MAP3K8/MEKK8) (MAP3K8 产品)
    别名
    MAP3K8 antibody, COT antibody, EST antibody, ESTF antibody, MEKK8 antibody, TPL2 antibody, Tpl-2 antibody, c-COT antibody, Cot antibody, Cot/Tpl2 antibody, Est antibody, Estf antibody, Tpl2 antibody, D17TPL2 antibody, mitogen-activated protein kinase kinase kinase 8 antibody, MAP3K8 antibody, map3k8 antibody, Map3k8 antibody
    背景
    COT, a member of the MAPKKK subfamily of Ser/Thr protein kinases, is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. It plays a role in the cell cycle. The longer form of cot has some transforming activity, although it is much weaker than the activated cot oncoprotein. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.
    分子量
    52925
    基因ID
    1326
    NCBI登录号
    NP_001231063, NP_005195
    UniProt
    P41279
    途径
    PI3K-Akt Signaling, TCR Signaling
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