ALDH1A3 抗体 (N-Term)
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- 抗原 See all ALDH1A3 抗体
- ALDH1A3 (Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3))
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抗原表位
- AA 24-51, N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ALDH1A3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This ALDH1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human ALDH1A3.
- 克隆位点
- RB16818
- 亚型
- Ig Fraction
- Top Product
- Discover our top product ALDH1A3 Primary Antibody
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- 应用备注
- WB: 1:1000. IHC-P: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid freeze-thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
- 有效期
- 6 months
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Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma." in: Oncotarget, Vol. 8, Issue 4, pp. 6914-6928, (2018) (PubMed).
: "ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment." in: Oncogene, Vol. 36, Issue 41, pp. 5695-5708, (2017) (PubMed).
: "ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes." in: Biology of reproduction, Vol. 94, Issue 1, pp. 12, (2016) (PubMed).
: "Aldh1 Expression and Activity Increase During Tumor Evolution in Sarcoma Cancer Stem Cell Populations." in: Scientific reports, Vol. 6, pp. 27878, (2016) (PubMed).
: "Induced Expression of Cancer Stem Cell Markers ALDH1A3 and Sox-2 in Hierarchical Reconstitution of Apoptosis-resistant Human Breast Cancer Cells." in: Acta histochemica et cytochemica, Vol. 49, Issue 5, pp. 149-158, (2016) (PubMed).
: "Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15." in: Journal of cancer research and clinical oncology, Vol. 141, Issue 9, pp. 1613-31, (2015) (PubMed).
: "Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations." in: Journal of lipid research, Vol. 56, Issue 2, pp. 342-57, (2015) (PubMed).
: "Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 20, Issue 15, pp. 4154-66, (2014) (PubMed).
: "Cellular level classification of breast cancer through proteomic markers using nanochannel array sensors." in: Nanomedicine (London, England), (2013) (PubMed).
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Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma." in: Oncotarget, Vol. 8, Issue 4, pp. 6914-6928, (2018) (PubMed).
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- 抗原
- ALDH1A3 (Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3))
- 别名
- ALDH1A3 (ALDH1A3 产品)
- 别名
- RALDH3 antibody, ALDH1A3 antibody, ALDH1A6 antibody, ALDH6 antibody, MCOP8 antibody, Aldh6 antibody, V1 antibody, aldehyde dehydrogenase 1 family member A3 antibody, aldehyde dehydrogenase 1 family member A3 L homeolog antibody, aldehyde dehydrogenase 1 family, member A3 antibody, aldehyde dehydrogenase family 1, subfamily A3 antibody, ALDH1A3 antibody, aldh1a3.L antibody, aldh1a3 antibody, Aldh1a3 antibody
- 背景
- Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein form.
- 分子量
- 56108
- 基因ID
- 220
- NCBI登录号
- NP_000684
- UniProt
- P47895
- 途径
- Retinoic Acid Receptor Signaling Pathway
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