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LIM Domain Kinase 1 抗体 (N-Term)

LIMK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3078 unconjugated
产品编号 ABIN392258
发货至: 中国
  • 抗原 See all LIM Domain Kinase 1 (LIMK1) 抗体
    LIM Domain Kinase 1 (LIMK1)
    抗原表位
    • 24
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    AA 1-30, N-Term
    适用
    • 106
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    • 2
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    • 1
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    宿主
    • 101
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    克隆类型
    • 105
    • 19
    多克隆
    标记
    • 58
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    • 3
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    This LIM Domain Kinase 1 antibody is un-conjugated
    应用范围
    • 89
    • 49
    • 26
    • 26
    • 25
    • 18
    • 16
    • 8
    • 7
    • 6
    • 6
    • 3
    • 1
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    M, Rat
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This LIM Kinase 1 (LIMK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LIM Kinase 1 (LIMK1).
    克隆位点
    RB3078
    亚型
    Ig Fraction
    Top Product
    Discover our top product LIMK1 Primary Antibody
  • 应用备注
    WB: 1:1000. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    LIM Domain Kinase 1 (LIMK1)
    别名
    LIM Kinase 1 (LIMK1) (LIMK1 产品)
    别名
    limk1 antibody, xlimk1 antibody, GB16654 antibody, LIMK1 antibody, LIMK antibody, LIMK-1 antibody, LIM domain kinase 1 antibody, LIM domain kinase 1a antibody, LIM domain kinase 1 L homeolog antibody, LIM-domain containing, protein kinase antibody, LIMK1 antibody, limk1a antibody, limk1 antibody, CpipJ_CPIJ000717 antibody, LOC413152 antibody, Limk1 antibody, limk1.L antibody
    背景
    LIMK1, a member of the Ser/Thr protein kinase family, may be a component of an intracellular signaling pathway and may be involved in brain development. It phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes. The LIM domain interacts with the cytoplasmic domain of NRG1, and this cytoplasmic protein also binds ROCK1, whic phosphorylates LIMK1 on serine and/or threonine residues. Highest expression occurs in both adult and fetal nervous systems. It is detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex, and is expressed to a lesser extent in heart and skeletal muscle. Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23. This protein contains 2 LIM zinc-binding domains and 1 PDZ/DHR domain.
    分子量
    72585
    基因ID
    3984
    NCBI登录号
    NP_001191355, NP_002305
    UniProt
    P53667
    途径
    Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events
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