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ERBB3 抗体 (N-Term)

Name: ERBB3 抗体 (N-Term)
SKU: ABIN391949
Availability: OutOfStock

ERBB3 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB01467 unconjugated

Western blot analysis of anti-ErbB3 Pab (ABIN391949 and ABIN2841747) in mouse brain lysate. (ERBB3 抗体 (N-Term))

Flow cytometric analysis of 293 cells using ErbB3 Antibody (N-term) (bottom histogram) compared to a negative control cell (top histogram). (ERBB3 抗体 (N-Term))

FACS

Formalin-fixed and paraffin-embedded human breast carcinoma with ErbB3 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (ERBB3 抗体 (N-Term))

IHC (p)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (ERBB3 抗体 (N-Term))

IHC (p)

5 images

(4 references)

产品编号 ABIN391949

发货至: 中国

Datasheet as PDF

抗原 See all ERBB3 抗体

ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
抗原表位
32

28

20

15

15

12

8

8

7

6

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 24-55, N-Term
适用
185

132

116

17

6

4

3

3

2

2

2

1

1

1
人, 小鼠
宿主
190

28

1

1
兔
Compatible Secondaries
克隆类型
190

30
多克隆
标记
109

13

7

7

7

7

7

7

5

5

4

4

4

4

4

4

4

4

4

4

4

1

1
This ERBB3 antibody is un-conjugated
应用范围
97

70

53

53

51

30

29

19

19

16

8

3

3

3

2

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This ERBB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-55 amino acids from the N-terminal region of human ERBB3.

克隆位点

RB01467

亚型

Ig Fraction

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anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 707-964) antibody
ERBB3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1289) antibody
ERBB3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-130) antibody
ERBB3 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2E9 unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) antibody
ERBB3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 24-55) antibody
ERBB3 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 661-760) antibody
ERBB3 适用: 人, 小鼠, 大鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1328) antibody
ERBB3 适用: 人, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 21-331) antibody
ERBB3 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2A4 unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) antibody
Verified ERBB3 适用: 人 IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-131) antibody
ERBB3 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2E9 unconjugated

应用备注

WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:50~100. IHC-P: 1:50~100. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Davies, Holmes, Lomo, Steinkamp, Kang, Muller, Wilson: "High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer." in: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, Vol. 33, Issue 4, pp. 402-10, (2014) (PubMed).

Lee, Chin, Li: "Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking." in: The Journal of cell biology, Vol. 199, Issue 5, pp. 799-816, (2012) (PubMed).

Xu, Watanabe, Iso, Koba, Sakai, Nagashima, Arita, Hongo, Ota, Kobayashi, Miyazaki, Hirano: "Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis." in: Circulation research, Vol. 105, Issue 5, pp. 500-10, (2009) (PubMed).

Sei, Ren-Patterson, Li, Tunbridge, Egan, Kolachana, Weinberger: "Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms." in: Molecular psychiatry, Vol. 12, Issue 10, pp. 946-57, (2007) (PubMed).
抗原

ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

别名

ErbB3 (ERBB3 产品)

别名

ErbB-3 antibody, HER3 antibody, LCCS2 antibody, MDA-BF-1 antibody, c-erbB-3 antibody, c-erbB3 antibody, erbB3-S antibody, p180-ErbB3 antibody, p45-sErbB3 antibody, p85-sErbB3 antibody, ERBB3 antibody, C76256 antibody, Erbb-3 antibody, Erbb3r antibody, Her3 antibody, nuc-ErbB3 antibody, erb-b2 receptor tyrosine kinase 3 antibody, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody, ERBB3 antibody, Erbb3 antibody

背景

ErbB3, a member of the EGF receptor family, binds and is activated by neuregulins and NTAK. It potentially forms a heterodimer with each of the other ERBB receptors. This protein is predominantly expressed in epithelial tissues and brain. The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. Ligand-binding may increase phosphorylation on tyrosine residues and promote its association with the p85 subunit of phosphatidylinositol 3-kinase ErbB3 is overexpressed in a subset of human mammary tumors.

分子量

148098

基因ID

2065

NCBI登录号

NP_001005915, NP_001973

UniProt

P21860

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway