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Caspase 3 抗体 (AA 60-90)

Name: Caspase 3 抗体 (AA 60-90)
SKU: ABIN391813
Availability: OutOfStock

CASP3 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB14696 unconjugated

All lanes : Anti-CASP3 Antibody (Center) at 1:2000 dilution Lane 1: HL-60 whole cell lysate Lane 2: Jurkat whole cell lysate Lane 3: A431 whole cell lysate Lysates/proteins at 20 μg per lane. (Caspase 3 抗体 (AA 60-90))

Flow cytometric analysis of NCI- cells using Caspase-3 (CASP3) Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). (Caspase 3 抗体 (AA 60-90))

FACS

Western blot analysis of anti-CASP3 Pab (ABIN391813 and ABIN2841662) in NCI- cell line lysates (35 μg/lane). (Caspase 3 抗体 (AA 60-90))

Western blot analysis of CASP3 (arrow) using rabbit polyclonal CASP3 Antibody (Center) (ABIN391813 and ABIN2841662). (Caspase 3 抗体 (AA 60-90))

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CASP3 antibody (Center) (ABIN391813 and ABIN2841662) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (Caspase 3 抗体 (AA 60-90))

IHC (p)

5 images

(5 references)

产品编号 ABIN391813

发货至: 中国

Datasheet as PDF

抗原 See all Caspase 3 (CASP3) 抗体

Caspase 3 (CASP3)
抗原表位
19

16

16

16

16

16

15

15

13

12

12

10

9

8

8

7

6

6

6

5

5

4

4

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 60-90
适用
254

172

129

17

11

10

9

8

7

5

5

4

3

3

2

2

1

1
人
宿主
257

36

4

2

2
兔
Compatible Secondaries
克隆类型
255

45
多克隆
标记
149

23

20

13

10

6

5

5

5

5

5

5

5

5

5

5

5

5

3

3

3

3

3

2

2

1
This Caspase 3 antibody is un-conjugated
应用范围
226

107

99

83

67

65

47

33

29

27

26

19

10

6

3

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This Caspase-3 (CASP3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids from the Central region of human Caspase-3 (CASP3).

克隆位点

RB14696

亚型

Ig Fraction

Top Product

Discover our top product CASP3 Primary Antibody
anti-Caspase 3 (CASP3) (AA 60-100) antibody
CASP3 适用: 人, 小鼠, 大鼠, Cow, 山羊 WB, IF (cc) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 67-175) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 220-236), (C-Term) antibody
CASP3 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 11-120) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal 5E1 unconjugated

anti-Caspase 3 (CASP3) (cleaved) antibody
CASP3 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (Internal Region) antibody
CASP3 适用: 人, 小鼠, 大鼠, Cow WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (pSer150) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 100-200) antibody
CASP3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 29-175) antibody
CASP3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:2000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Zhao, Xia, Zhang, Xiong, Li, Yan, Chen, Wang, Wang, Gao, Lee, Li, Wang, Zhang, Tao: "Nucleostemin dysregulation contributes to ischemic vulnerability of diabetic hearts: Role of ribosomal biogenesis." in: Journal of molecular and cellular cardiology, Vol. 108, pp. 106-113, (2018) (PubMed).

Ling, Song, Fan, Feng, Liu, Yang, Wang, Li, Tian, Zhao, Liu, Huang, Hou, Xu, Shi, Li: "Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway." in: International journal of oncology, Vol. 50, Issue 1, pp. 297-309, (2017) (PubMed).

Guo, Shao, Chen, Xu, Zhang, Liu: "Expression of pituitary tumor-transforming 2 in human glioblastoma cell lines and its role in glioblastoma tumorigenesis." in: Experimental and therapeutic medicine, Vol. 11, Issue 5, pp. 1847-1852, (2016) (PubMed).

Liu, Xie, Wang, Liu, Liu, Sun, Niu: "Ubenimex inhibits cell proliferation, migration and invasion in renal cell carcinoma: the effect is autophagy-associated." in: Oncology reports, Vol. 33, Issue 3, pp. 1372-80, (2015) (PubMed).

Tai, Sun, Liu, Ding, Hsia, Bhuta, Thor, Damoiseaux, Liang, Huang: "Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells." in: Molecular cancer therapeutics, Vol. 11, Issue 6, pp. 1320-31, (2012) (PubMed).
抗原

Caspase 3 (CASP3)

别名

Caspase-3 (CASP3) (CASP3 产品)

别名

CPP32 antibody, CPP32B antibody, SCA-1 antibody, A830040C14Rik antibody, AC-3 antibody, Apopain antibody, CC3 antibody, Caspase-3 antibody, Lice antibody, Yama antibody, mldy antibody, xcpp32 antibody, casp3 antibody, zgc:100890 antibody, CASP-3 antibody, caspase-3 antibody, caspase 3 antibody, caspase 3 S homeolog antibody, caspase 3, apoptosis-related cysteine peptidase a antibody, caspase 3, apoptosis-related cysteine peptidase antibody, CASP3 antibody, Casp3 antibody, casp3.S antibody, casp3a antibody

背景

CASP3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

分子量

31608

基因ID

836

NCBI登录号

NP_004337, NP_116786

UniProt

P42574

途径

Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation