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CDK4 抗体 (C-Term)

Name: CDK4 抗体 (C-Term)
SKU: ABIN391751
Availability: OutOfStock

CDK4 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB03154 unconjugated

Western blot analysis of anti-CDK4 Pab (ABIN391751 and ABIN2841625) in HL-60 cell lysate. (CDK4 抗体 (C-Term))

CDK4 Antibody (C-term) (ABIN391751 and ABIN2841625) flow cytometric analysis of HL60 cells (bottom histogram) compared to a negative control cell (top histogram). (CDK4 抗体 (C-Term))

FACS

Fluorescent image of Hela cell stained with CDK4 Antibody (C-term) (ABIN391751 and ABIN2841625). (CDK4 抗体 (C-Term))

Western blot analysis of CDK4 (arrow) using rabbit polyclonal CDK4 Antibody (C-term) (ABIN391751 and ABIN2841625). (CDK4 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human prostate carcinoma with CDK4 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (CDK4 抗体 (C-Term))

IHC (p)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (CDK4 抗体 (C-Term))

IHC (p)

6 images

(3 references)

产品编号 ABIN391751

发货至: 中国

Datasheet as PDF

抗原 See all CDK4 抗体

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
抗原表位
18

16

15

9

9

7

5

5

4

4

3

3

3

2

2

2

2

2

1

1

1

1

1
AA 273-305, C-Term
适用
106

67

51

19

8

6

4

4

2

1

1

1
人
宿主
93

33

2

1
兔
Compatible Secondaries
克隆类型
96

32
多克隆
标记
74

10

9

5

5

4

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CDK4 antibody is un-conjugated
应用范围
107

47

30

23

16

15

15

13

13

10

4

4

2

2

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This CDK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-305 amino acids from the C-terminal region of human CDK4.

克隆位点

RB03154

亚型

Ig Fraction

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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305) antibody
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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 241-303) antibody
CDK4 适用: 人, 小鼠, 大鼠, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303), (C-Term) antibody
CDK4 适用: 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303) antibody
CDK4 适用: 人, 大鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (C-Term) antibody
CDK4 适用: 人, 大鼠, 绵羊, Pig, 犬, Cow, 兔, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Ling, Song, Fan, Feng, Liu, Yang, Wang, Li, Tian, Zhao, Liu, Huang, Hou, Xu, Shi, Li: "Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway." in: International journal of oncology, Vol. 50, Issue 1, pp. 297-309, (2017) (PubMed).

Patel, Asbach, Shteyn, Gomez, Coltoff, Bhuyan, Tyner, Wagner, Blain: "Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4." in: Molecular and cellular biology, Vol. 35, Issue 9, pp. 1506-22, (2015) (PubMed).

Ling, Feng, Ke, Fan, Li, Li, Dong, Wang, Xu, Li, Wang: "Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines." in: Oncology reports, Vol. 31, Issue 6, pp. 2611-8, (2014) (PubMed).
抗原

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

别名

CDK4 (CDK4 产品)

别名

zgc:153726 antibody, CMM3 antibody, PSK-J3 antibody, Crk3 antibody, 8-6 antibody, CDK4 antibody, CDK4/6 antibody, CG5072 antibody, Cdk4/6 antibody, DmCdk4 antibody, Dmel\\CG5072 antibody, Pk53C antibody, Pk?7 antibody, cdk antibody, cdk4 antibody, cdk4/6 antibody, dCdk4 antibody, l(2)05428 antibody, l(2)0671 antibody, l(2)k06503 antibody, l(2)s4639 antibody, l(2)sh0671 antibody, xcdk4 antibody, cyclin-dependent kinase 4 antibody, cyclin dependent kinase 4 antibody, Cyclin-dependent kinase 4 antibody, cyclin-dependent kinase 4 L homeolog antibody, cdk4 antibody, CDK4 antibody, Cdk4 antibody, cdk4.L antibody

背景

CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of the gene have been reported.

分子量

33730

基因ID

1019

NCBI登录号

NP_000066

UniProt

P11802

途径

Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size