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SMAD2 抗体 (AA 201-230)

SMAD2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB18943 unconjugated
产品编号 ABIN391546
发货至: 中国
  • 抗原 See all SMAD2 抗体
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    抗原表位
    • 51
    • 48
    • 29
    • 27
    • 25
    • 22
    • 9
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    • 1
    • 1
    • 1
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    AA 201-230
    适用
    • 257
    • 168
    • 136
    • 13
    • 11
    • 10
    • 10
    • 8
    • 8
    • 8
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    • 1
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    人, 小鼠
    宿主
    • 257
    • 12
    克隆类型
    • 235
    • 34
    多克隆
    标记
    • 123
    • 17
    • 12
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    This SMAD2 antibody is un-conjugated
    应用范围
    • 207
    • 101
    • 65
    • 54
    • 53
    • 44
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    • 39
    • 17
    • 15
    • 10
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    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    B, Zf, Rat
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This SMAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from human SMAD2.
    克隆位点
    RB18943
    亚型
    Ig Fraction
    Top Product
    Discover our top product SMAD2 Primary Antibody
  • 应用备注
    WB: 1:1000. WB: 1:1000-2000. IHC-P-Leica: 1:250
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    别名
    SMAD2 (SMAD2 产品)
    别名
    JV18 antibody, JV18-1 antibody, MADH2 antibody, MADR2 antibody, hMAD-2 antibody, hSMAD2 antibody, jv18 antibody, Xmad2 antibody, madh2 antibody, madr2 antibody, XSmad2 antibody, hmad-2 antibody, hsmad2 antibody, jv18-1 antibody, smad-2 antibody, fj43c06 antibody, wu:fj43c06 antibody, 7120426M23Rik antibody, Madh2 antibody, Madr2 antibody, Smad-2 antibody, mMad2 antibody, MAD homolog 2 antibody, Mothers against DPP homolog 2 antibody, SMAD 2 antibody, Smad2 antibody, SMAD family member 2 antibody, SMAD family member 2-Z antibody, SMAD family member 2 S homeolog antibody, SMAD2 antibody, SMAD2Z antibody, smad2 antibody, smad2.S antibody, Smad2 antibody
    背景
    The protein belongs to the SMAD, a family of proteins similar to the proteins of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.
    分子量
    52306
    基因ID
    4087
    NCBI登录号
    NP_001003652, NP_005892
    UniProt
    Q15796
    途径
    Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
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