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PTTG1 抗体 (N-Term)

PTTG1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB18596 unconjugated
产品编号 ABIN391532
发货至: 中国
  • 抗原 See all PTTG1 抗体
    PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
    抗原表位
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 16-45, N-Term
    适用
    • 45
    • 11
    • 10
    • 1
    宿主
    • 34
    • 11
    • 1
    克隆类型
    • 29
    • 17
    多克隆
    标记
    • 28
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This PTTG1 antibody is un-conjugated
    应用范围
    • 21
    • 19
    • 11
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This PTTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human PTTG1.
    克隆位点
    RB18596
    亚型
    Ig Fraction
    Top Product
    Discover our top product PTTG1 Primary Antibody
  • 应用备注
    IF: 1:100. WB: 1:500. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Cui, Xu, Song, Zhao, Liu, Song: "Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 6, pp. 414-21, (2015) (PubMed).

  • 抗原
    PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
    别名
    PTTG1 (PTTG1 产品)
    别名
    EAP1 antibody, HPTTG antibody, PTTG antibody, TUTR1 antibody, PTTG1 antibody, securin antibody, AW555095 antibody, C87862 antibody, Pttg antibody, Pttg3 antibody, Securin antibody, Protein Cut2 antibody, pituitary tumor-transforming 1 antibody, pituitary tumor-transforming gene 1 antibody, securin, sister chromatid separation inhibitor antibody, PTTG1 antibody, Pttg1 antibody, cut2 antibody
    背景
    PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.
    分子量
    22024
    基因ID
    9232
    NCBI登录号
    NP_001269311, NP_001269312, NP_004210
    UniProt
    O95997
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