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DCLK1 抗体 (AA 690-720)

Name: DCLK1 抗体 (AA 690-720)
SKU: ABIN391324
Availability: OutOfStock

DCLK1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB3161 unconjugated

All lanes : Anti-hDCKL1- at 1:8000 dilution Lane 1: Human brain lysate Lane 2: Mouse brain lysate Lane 3: Rat brain lysate Lane 4: TT whole cell lysate Lysates/proteins at 20 μg per lane. (DCLK1 抗体 (AA 690-720))

All lanes :DCKL1 Antibody (C-term) at 1:2000 dilution Lane 1: Human brain lysate Lane 2: Mouse brain lysate Lysates/proteins at 20 μg per lane. (DCLK1 抗体 (AA 690-720))

All lanes :DCKL1 Antibody (C-term) at 1:1000 dilution Lane 1: Human brain lysate Lane 2: Mouse brain lysate Lysates/proteins at 20 μg per lane. (DCLK1 抗体 (AA 690-720))

3 images

(15 references)

产品编号 ABIN391324

发货至: 中国

Datasheet as PDF

抗原 See all DCLK1 抗体

DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))
抗原表位
15

11

9

7

7

5

5

5

3

2

2

2

1

1

1

1
AA 690-720
适用
78

44

12

2

2

2

2

1

1

1

1

1
人, 小鼠, 大鼠
宿主
76

7

1
兔
Compatible Secondaries
克隆类型
70

14
多克隆
标记
32

8

7

6

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This DCLK1 antibody is un-conjugated
应用范围
65

38

18

15

13

13

8

7

4

3

3

1
Western Blotting (WB)

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This DCAMKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 690-720 amino acids of human DCAMKL1.

克隆位点

RB3161

亚型

Ig Fraction

Top Product

Discover our top product DCLK1 Primary Antibody
anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 390-647) antibody
DCLK1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 640-729) antibody
DCLK1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6H4 unconjugated

anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 143-381) antibody
DCLK1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 390-647) antibody
DCLK1 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Doublecortin-Like Kinase 1 (DCLK1) antibody
DCLK1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated

anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 1-30), (N-Term) antibody
DCLK1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB3059 unconjugated

anti-Doublecortin-Like Kinase 1 (DCLK1) antibody
DCLK1 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 1751CT665-1-72 unconjugated

anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 640-729) antibody
DCLK1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 640-729) antibody
DCLK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6F9 unconjugated

anti-Doublecortin-Like Kinase 1 (DCLK1) (AA 630-729) antibody
DCLK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:2000. WB: 1:1000. WB: 1:8000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze-thaw cycles.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

有效期

6 months
Kawamura, Takemoto, Nishimoto, Ueno, Hosoyama, Shirasawa, Tanaka, Kugimiya, Harada, Hamano: "Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells." in: Oncology reports, Vol. 38, Issue 5, pp. 3238-3244, (2018) (PubMed).

Ushiama, Ishimaru, Narukawa, Yoshioka, Kozuka, Watanabe, Tsunoda, Osakabe, Asakura, Masuzaki, Abe: "Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice." in: EBioMedicine, Vol. 8, pp. 60-71, (2017) (PubMed).

Gao, Wang, Xu, Wen, Liu, An: "DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer." in: Journal of cancer research and clinical oncology, Vol. 142, Issue 10, pp. 2131-40, (2017) (PubMed).

Leppänen, Helminen, Huhta, Kauppila, Miinalainen, Ronkainen, Saarnio, Lehenkari, Karttunen: "Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 124, Issue 11, pp. 958-965, (2017) (PubMed).

Schellnegger, Quante, Rospleszcz, Schernhammer, Höhl, Tobiasch, Pastula, Brandtner, Abrams, Strauch, Schmid, Vieth, Wang, Quante: "Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma." in: Cancer prevention research (Philadelphia, Pa.), Vol. 10, Issue 1, pp. 55-66, (2017) (PubMed).

Nakata, Shimizu, Nagata, Ito, Fujii, Suzuki, Kawamoto, Ishibashi, Kuno, Anzai, Murano, Mizutani, Oshima, Tsuchiya, Nakamura, Hozumi, Watanabe, Okamoto: "Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine." in: Data in brief, Vol. 10, pp. 551-556, (2017) (PubMed).

Gross, Balderes, Liu, Asfaha, Gu, Wang, Sussel: "Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential." in: American journal of physiology. Gastrointestinal and liver physiology, pp. ajpgi.00244.2015, (2015) (PubMed).

Shimizu, Okamoto, Ito, Fujii, Nakata, Suzuki, Murano, Mizutani, Tsuchiya, Nakamura, Hozumi, Watanabe: "Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine." in: PeerJ, Vol. 2, pp. e370, (2014) (PubMed).

Gonzalez, Williamson, Piedrahita, Blikslager, Magness: "Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration." in: PLoS ONE, Vol. 8, Issue 6, pp. e66465, (2013) (PubMed).

Trivedi, Wiber, El-Zimaity, Brubaker: "Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 302, Issue 8, pp. G840-9, (2012) (PubMed).

Yu, Chen, Zhang, Li, Xu, Wang, Ai, Liu: "Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity." in: PLoS ONE, Vol. 7, Issue 2, pp. e32492, (2012) (PubMed).

Gerbe, van Es, Makrini, Brulin, Mellitzer, Robine, Romagnolo, Shroyer, Bourgaux, Pignodel, Clevers, Jay: "Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium." in: The Journal of cell biology, Vol. 192, Issue 5, pp. 767-80, (2011) (PubMed).

Gerbe, Brulin, Makrini, Legraverend, Jay: "DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium." in: Gastroenterology, Vol. 137, Issue 6, pp. 2179-80; author reply 2180-1, (2009) (PubMed).

Dekaney, Gulati, Garrison, Helmrath, Henning: "Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 297, Issue 3, pp. G461-70, (2009) (PubMed).

May, Riehl, Hunt, Sureban, Anant, Houchen et al.: "Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple ..." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 3, pp. 630-7, (2008) (PubMed).
抗原

DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

别名

DCAMKL1 (DCLK1 产品)

别名

DCLK1 antibody, DCAMKL1 antibody, dcamkl1 antibody, dclk1 antibody, wu:fc51f11 antibody, zgc:153709 antibody, MGC145348 antibody, CL1 antibody, CLICK1 antibody, DCDC3A antibody, DCLK antibody, 1700113D08Rik antibody, 2810480F11Rik antibody, AI836758 antibody, Click-I antibody, Cpg16 antibody, Dcamkl1 antibody, Dcl antibody, Dclk antibody, mKIAA0369 antibody, Ania4 antibody, doublecortin like kinase 1 antibody, doublecortin-like kinase 1a antibody, serine/threonine-protein kinase DCLK1 antibody, doublecortin-like kinase 2 antibody, doublecortin-like kinase 1 antibody, DCLK1 antibody, dclk1a antibody, LOC587664 antibody, dclk2 antibody, LOC100539645 antibody, Dclk1 antibody

背景

Doublecortin-like kinase (DCAMKL1)(Ser/Thr protein kinase family) is essential for proper neurogenesis, neuronal migration, and axonal wiring. DCAMKL1 is involved in a calcium-signaling pathway controling neuronal migration in the developing brain, and participates in functions of the mature nervous system. DCAMKL1 protein shares high homology with doublecortin (DCX). DCLK, but not DCX, is highly expressed in regions of active neurogenesis in the neocortex and cerebellum. DCAMKL1 controls mitotic division by regulating spindle formation and also determines the fate of neural progenitors during cortical neurogenesis.

分子量

82224

基因ID

9201

NCBI登录号

NP_001182344, NP_001182345, NP_004725

UniProt

O15075