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PIM3 抗体 (C-Term)

PIM3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB8591 unconjugated
产品编号 ABIN391253
发货至: 中国
  • 抗原 See all PIM3 抗体
    PIM3 (Pim-3 Oncogene (PIM3))
    抗原表位
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    AA 259-288, C-Term
    适用
    • 27
    • 11
    • 2
    人, 小鼠
    宿主
    • 25
    • 2
    克隆类型
    • 25
    • 2
    多克隆
    标记
    • 11
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIM3 antibody is un-conjugated
    应用范围
    • 15
    • 15
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    Rat
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This PIM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-288 amino acids from the C-terminal region of human PIM3.
    克隆位点
    RB8591
    亚型
    Ig Fraction
    Top Product
    Discover our top product PIM3 Primary Antibody
  • 应用备注
    WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Ishikawa, Senba, Hashimoto, Imaizumi, Mori: "Expression and significance of Pim-3 kinase in adult T-cell leukemia." in: European journal of haematology, Vol. 99, Issue 6, pp. 495-504, (2018) (PubMed).

    Decker, Finter, Forde, Kissel, Schwaller, Mack, Kuhn, Gray, Follo, Jumaa, Burger, Zirlik, Pfeifer, Miduturu, Eibel, Veelken, Dierks: "PIM kinases are essential for chronic lymphocytic leukemia cell survival (PIM2/3) and CXCR4-mediated microenvironmental interactions (PIM1)." in: Molecular cancer therapeutics, Vol. 13, Issue 5, pp. 1231-45, (2014) (PubMed).

    Brault, Menter, Obermann, Knapp, Thommen, Schwaller, Tzankov: "PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma." in: British journal of cancer, Vol. 107, Issue 3, pp. 491-500, (2012) (PubMed).

    Chen, Redkar, Bearss, Wierda, Gandhi: "Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells." in: Blood, Vol. 114, Issue 19, pp. 4150-7, (2009) (PubMed).

    Cheng, Weidner-Glunde, Varjosalo, Rainio, Lehtonen, Schulz, Koskinen, Taipale, Ojala: "KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA." in: PLoS pathogens, Vol. 5, Issue 3, pp. e1000324, (2009) (PubMed).

  • 抗原
    PIM3 (Pim-3 Oncogene (PIM3))
    别名
    PIM3 (PIM3 产品)
    别名
    pim1-a antibody, pim-3 antibody, BC026639 antibody, Kid1 antibody, Serine/threonine-protein kinase Pim-3 antibody, Pim-3 proto-oncogene, serine/threonine kinase S homeolog antibody, Pim-3 proto-oncogene, serine/threonine kinase antibody, pim-3 oncogene antibody, proviral integration site 3 antibody, pim3 antibody, pim3.S antibody, PIM3 antibody, Pim3 antibody
    背景
    PIM3 is a memberof the Ser/Thr protein kinase family that may be involved in cell cycle progression and anti-apoptosis process. This protein has been implicated in proliferation of human hepatoma cell lines. PIM3 is widely expressed, with the exception of no expression observed in colon, thymus, and small intestine. PIM3 is expressed in human hepatoma cell lines but not in normal liver tissues.
    分子量
    35891
    基因ID
    415116
    NCBI登录号
    NP_001001852
    UniProt
    Q86V86
    途径
    Negative Regulation of Hormone Secretion
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