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- 抗原 See all Deoxyguanosine Kinase (DGUOK) 抗体
- Deoxyguanosine Kinase (DGUOK)
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抗原表位
- AA 241-271, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Deoxyguanosine Kinase antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This Deoxyguanosine Kinase (DGUOK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-271 amino acids from the C-terminal region of human Deoxyguanosine Kinase (DGUOK).
- 克隆位点
- RB5280
- 亚型
- Ig Fraction
- Top Product
- Discover our top product DGUOK Primary Antibody
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anti-Deoxyguanosine Kinase (DGUOK) (AA 1-89) antibody
DGUOK 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 3E9 unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (AA 40-277) antibodyDGUOK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) antibodyDGUOK 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (C-Term) antibodyDGUOK 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (AA 40-277) antibodyDGUOK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (AA 1-30), (N-Term) antibodyDGUOK 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB5277 unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- Deoxyguanosine Kinase (DGUOK)
- Abstract
- DGUOK 产品
- 别名
- DGUOK antibody, zgc:86625 antibody, dgk antibody, DDBDRAFT_0218264 antibody, DDBDRAFT_0233982 antibody, DDB_0218264 antibody, DDB_0233982 antibody, MTDPS3 antibody, dGK antibody, dGK1 antibody, dGK2 antibody, dGK3 antibody, deoxyguanosine kinase antibody, deoxyguanosine kinase L homeolog antibody, DGUOK antibody, dguok antibody, dguok.L antibody, dgk antibody, Ccan_04750 antibody, Dguok antibody
- 背景
- Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.
- 分子量
- 32056
- 基因ID
- 1716
- NCBI登录号
- NP_550438, NP_550440
- UniProt
- Q16854
- 途径
- Ribonucleoside Biosynthetic Process
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