Calreticulin 抗体 (AA 277-305)
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- 抗原 See all Calreticulin (CALR) 抗体
- Calreticulin (CALR)
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抗原表位
- AA 277-305
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Calreticulin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 预测反应
- Pr
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This CALR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the Central region of human CALR.
- 克隆位点
- RB21112
- 亚型
- Ig Fraction
- Top Product
- Discover our top product CALR Primary Antibody
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anti-Calreticulin (CALR) (AA 196-310) antibody
CALR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calreticulin (CALR) (AA 18-193) antibodyCALR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calreticulin (CALR) (AA 18-417) antibodyCALR 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7B3D7 unconjugated
anti-Calreticulin (CALR) antibodyCALR 适用: 人 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 1G6A7 unconjugated
anti-Calreticulin (CALR) (N-Term) antibodyCALR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calreticulin (CALR) (AA 1-417) antibodyCALR 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G11-1A9 unconjugated
anti-Calreticulin (CALR) antibodyCALR 适用: 人 WB, IHC, IP, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calreticulin (CALR) antibody (HRP)CALR 适用: 人 WB, IHC, IP, FACS, IF, ICC 宿主: 兔 Polyclonal HRP
anti-Calreticulin (CALR) antibody (FITC)CALR 适用: 人 WB, IHC, IP, FACS, IF, ICC 宿主: 兔 Polyclonal FITC
anti-Calreticulin (CALR) antibody (Biotin)CALR 适用: 人 WB, IHC, IP, FACS, IF, ICC 宿主: 兔 Polyclonal Biotin
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- 应用备注
- WB: 1:2000. WB: 1:1000. WB: 1:2000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:25
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- Calreticulin (CALR)
- 别名
- CALR (CALR 产品)
- 别名
- CRT antibody, RO antibody, SSA antibody, cC1qR antibody, crc antibody, crt antibody, Calregulin antibody, CG9429 antibody, Clr antibody, Dmel\\CG9429 antibody, anon-EST:Liang-2.11 antibody, anon-EST:Liang-2.17 antibody, anon-EST:fe3D7 antibody, clone 2.11 antibody, clone 2.17 antibody, eth antibody, potp antibody, cc1qr antibody, ssa antibody, NV19007 antibody, CRP55 antibody, ERp60 antibody, HACBP antibody, CHOT1 antibody, CHT1 antibody, CT1 antibody, AA589632 antibody, CRTR antibody, Creat antibody, CCDS1 antibody, calrl2 antibody, fc66d10 antibody, wu:fc66d10 antibody, wu:fj50c03 antibody, zgc:66153 antibody, calreticulin antibody, calreticulin L homeolog antibody, Calreticulin antibody, putative calreticulin antibody, solute carrier family 6 member 8 antibody, solute carrier family 6 (neurotransmitter transporter, creatine), member 8 antibody, CALR antibody, calr.L antibody, Crt antibody, crt antibody, CRT antibody, Calr antibody, calr antibody, LMJF_31_2600 antibody, Crc antibody, Slc6a8 antibody, SLC6A8 antibody, LOC8269812 antibody
- 背景
- Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
- 分子量
- 48142
- 基因ID
- 811
- NCBI登录号
- NP_004334
- UniProt
- P27797
- 途径
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
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