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Caspase 8 抗体 (C-Term)

Name: Caspase 8 抗体 (C-Term)
SKU: ABIN390474
Availability: OutOfStock

CASP8 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB18993 unconjugated

All lanes : Anti-CASP8 Antibody (C-term) at 1:2000 dilution Lane 1: BA/F3 whole cell lysate Lane 2: C2C12 whole cell lysate Lane 3: Hela whole cell lysate Lane 4: Jurkat whole cell lysate Lysates/proteins at 20 μg per lane. (Caspase 8 抗体 (C-Term))

Overlay histogram showing Jurkat cells stained with (ABIN390474 and ABIN2840840) (green line). (Caspase 8 抗体 (C-Term))

FACS

2 images

(1 reference)

产品编号 ABIN390474

发货至: 中国

Datasheet as PDF

抗原 See all Caspase 8 (CASP8) 抗体

Caspase 8 (CASP8)
抗原表位
16

16

8

7

6

6

6

6

5

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 432-461, C-Term
适用
131

66

60

22

16

16

10

1

1
人, 小鼠
宿主
125

23

5

2
兔
Compatible Secondaries
克隆类型
124

30
多克隆
标记
91

15

11

4

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1
This Caspase 8 antibody is un-conjugated
应用范围
137

48

43

37

27

26

25

18

17

17

7

4

4

4

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS)

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This CASP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 amino acids from the C-terminal region of human CASP8.

克隆位点

RB18993

亚型

Ig Fraction

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应用备注

WB: 1:2000. FC: 1:25

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Lin, Huang, Lin, Lin: "p-Cresol mediates autophagic cell death in renal proximal tubular cells." in: Toxicology letters, Vol. 234, Issue 1, pp. 20-9, (2015) (PubMed).
抗原

Caspase 8 (CASP8)

别名

CASP8 (CASP8 产品)

别名

casp8-A antibody, xCaspase-8 antibody, casp8 antibody, CASP8 antibody, CASP-8 antibody, FLICE antibody, MACH antibody, Mch5 antibody, ALPS2B antibody, CAP4 antibody, Casp-8 antibody, MCH5 antibody, caspase-8 antibody, zgc:92075 antibody, caspase 8 L homeolog antibody, death related ced-3/Nedd2-like protein antibody, caspase 8 antibody, caspase-8 antibody, caspase-8-like antibody, caspase 8, apoptosis-related cysteine peptidase antibody, casp8.L antibody, LOC661095 antibody, CASP8 antibody, LOC5563818 antibody, casp8 antibody, LOC100222284 antibody, Casp8 antibody

背景

CASP8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases.

分子量

55391

基因ID

841

NCBI登录号

NP_001073593, NP_001073594, NP_001219, NP_203519, NP_203520, NP_203522

UniProt

Q14790

途径

Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades