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RCAN1 抗体 (C-Term)

Name: RCAN1 抗体 (C-Term)
SKU: ABIN390298
Availability: OutOfStock

RCAN1 适用: 人 WB 宿主: 兔 Polyclonal RB4671 unconjugated

The anti-DSCR1 Pab (ABIN390298 and ABIN2837935) is used in Western blot to detect RCAN1/DSCR1 in endothelial tissue lysate. (RCAN1 抗体 (C-Term))

1 image

(8 references)

产品编号 ABIN390298

发货至: 中国

Datasheet as PDF

抗原 See all RCAN1 抗体

RCAN1 (Regulator of Calcineurin 1 (RCAN1))
抗原表位
15

11

7

7

6

5

5

4

4

4

2

2

2

1

1

1

1

1

1

1

1

1
AA 222-252, C-Term
适用
78

20

18

5

4

4

4

4

3

2

2

2

1
人
宿主
73

5

1
兔
Compatible Secondaries
克隆类型
77

2
多克隆
标记
38

7

5

4

4

4

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This RCAN1 antibody is un-conjugated
应用范围
62

38

13

13

9

8

7

3

3

2
Western Blotting (WB)

预测反应

B, Ha, M, Rat, Sh

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This RCAN1/DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human DSCR1.

克隆位点

RB4671

亚型

Ig Fraction

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Discover our top product RCAN1 Primary Antibody
anti-Regulator of Calcineurin 1 (RCAN1) (AA 60-245) antibody
RCAN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (Middle Region) antibody
RCAN1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 绵羊, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 1-100) antibody
RCAN1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1B1 unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) antibody
RCAN1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 1-100) antibody
RCAN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G7 unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (C-Term) antibody
RCAN1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 1-117) antibody
RCAN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (C-Term) antibody
RCAN1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 41-68), (N-Term) antibody
RCAN1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB36242 unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 75-104) antibody
RCAN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Wang, Rai, Hur, Smilansky, Chang, Min: "DSCR1 is required for both axonal growth cone extension and steering." in: The Journal of cell biology, Vol. 213, Issue 4, pp. 451-62, (2017) (PubMed).

Lei, Hu, Chen, Yu, Qi, Du, Gu, Lin, Yang: "RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation." in: Molecular immunology, Vol. 77, pp. 26-33, (2017) (PubMed).

Hong, Lee, Chung: "Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination." in: Journal of cellular physiology, Vol. 230, Issue 7, pp. 1651-60, (2015) (PubMed).

Junkins, MacNeil, Wu, McCormick, Lin: "Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5178-86, (2013) (PubMed).

Stefos, Soppa, Dierssen, Becker: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, (2013) (PubMed).

Wang, Zhu, Chang, Min: "DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis." in: The EMBO journal, Vol. 31, Issue 18, pp. 3655-66, (2012) (PubMed).

Hirakawa, Nary, Medh: "Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis." in: Journal of molecular signaling, Vol. 4, pp. 6, (2009) (PubMed).

Yang, Chen, Edgar, Li, Molkentin, Berman, Lin: "Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function." in: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 195-207, (2009) (PubMed).
抗原

RCAN1 (Regulator of Calcineurin 1 (RCAN1))

别名

DSCR1 (RCAN1 产品)

别名

ADAPT78 antibody, CSP1 antibody, DSC1 antibody, DSCR1 antibody, MCIP1 antibody, RCN1 antibody, RCAN1 antibody, 2410048A02Rik antibody, AA408855 antibody, AI429645 antibody, AL024459 antibody, AV028423 antibody, Adapt78 antibody, CALP1L antibody, Dscr1 antibody, Mcip1 antibody, dscr1 antibody, rcan1 antibody, wu:fr92c05 antibody, adapt78 antibody, csp1 antibody, dsc1 antibody, mcip1 antibody, MGC53636 antibody, rcn1 antibody, MGC69428 antibody, regulator of calcineurin 1 antibody, regulator of calcineurin 1b antibody, regulator of calcineurin 1 L homeolog antibody, Down syndrome critical region gene 1 antibody, RCAN1 antibody, Rcan1 antibody, rcan1b antibody, rcan1.L antibody, dscr1 antibody, rcan1 antibody

背景

DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

分子量

28079

基因ID

1827

NCBI登录号

NP_004405, NP_981962, NP_981963

UniProt

P53805

途径

Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development