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ACE2 抗体 (C-Term)

Name: ACE2 抗体 (C-Term)
SKU: ABIN390049
Availability: OutOfStock

ACE2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4819 unconjugated

The anti-ACE2 C-term Pab f is used in Western blot to detect ACE2 in 293 cell lysate. (ACE2 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human testis tissue reacted with ACE2 (SARS Receptor) Antibody (C-term) f , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (ACE2 抗体 (C-Term))

IHC (p)

Western blot analysis of anti-ACE2 C-term Pab f in K562 cell line lysates (35 μg/lane). (ACE2 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (ACE2 抗体 (C-Term))

IHC (p)

4 images

(1 reference)

产品编号 ABIN390049

发货至: 中国

Datasheet as PDF

抗原 See all ACE2 抗体

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
抗原表位
16

13

11

8

8

7

6

5

5

4

4

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 773-805, C-Term
适用
133

52

46

5

4

1

1

1

1

1

1
人
宿主
120

19

6
兔
Compatible Secondaries
克隆类型
110

35
多克隆
标记
73

15

10

8

5

4

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This ACE2 antibody is un-conjugated
应用范围
113

64

48

35

29

19

17

10

10

10

9

6

3

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This ACE2 (SARS Receptor) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 773-805 amino acids from the C-terminal region of human ACE2 (SARS Receptor).

克隆位点

RB4819

亚型

Ig Fraction

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anti-Angiotensin I Converting Enzyme 2 (ACE2) antibody
ACE2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal AC18F unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-250) antibody
ACE2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 93-464) antibody
ACE2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 392-739) antibody
ACE2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (N-Term) antibody
Verified ACE2 适用: 人 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 59-90) antibody
ACE2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 140-172) antibody
ACE2 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 351-450) antibody
ACE2 适用: 人, 小鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 395-638) antibody
ACE2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Heurich, Hofmann-Winkler, Gierer, Liepold, Jahn, Pöhlmann: "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein." in: Journal of virology, Vol. 88, Issue 2, pp. 1293-307, (2013) (PubMed).
抗原

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

别名

ACE2 (SARS Receptor) (ACE2 产品)

别名

ACE1 antibody, CD143 antibody, DCP antibody, DCP1 antibody, ICH antibody, MVCD3 antibody, ACEH antibody, 2010305L05Rik antibody, zgc:92514 antibody, angiotensin I converting enzyme antibody, angiotensin I converting enzyme 2 antibody, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 antibody, ACE antibody, ACE2 antibody, Ace2 antibody, ace2 antibody

背景

ACE2 cDNA encodes a deduced 805-amino acid protein containing a potential 17-amino acid N-terminal signal peptide and a putative 22-amino acid C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin I to angiotensin II, ACE2 converts angiotensin I to angiotensin 1-9, which has 9 amino acids. Angiotensin II is a potent blood vessel constrictor, while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a blood vessel dilator. Spike (S) proteins of coronaviruses, including the SARS coronavirus, bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor for SARS coronavirus.

分子量

92463

基因ID

59272

NCBI登录号

NP_068576

UniProt

Q9BYF1

途径

ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour