(1 reference)-
- 抗原
- TBK
-
抗原表位
- pSer172
- 适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- 非结合性
-
应用范围
- Dot Blot (DB)
- 预测反应
- Zf, M, X
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This TBK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S172 of human TBK.
- 克隆位点
- RB16573
- 亚型
- Ig Fraction
-
anti-TBK antibody
适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-TBK (pSer172) antibody适用: 人 DB 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- DB: 1:500
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
-
-
: "Evaluating TBK1 as a therapeutic target in cancers with activated IRF3." in: Molecular cancer research : MCR, Vol. 12, Issue 7, pp. 1055-66, (2014) (PubMed).
-
: "Evaluating TBK1 as a therapeutic target in cancers with activated IRF3." in: Molecular cancer research : MCR, Vol. 12, Issue 7, pp. 1055-66, (2014) (PubMed).
-
- 抗原
- TBK
- 背景
- The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
- 分子量
- 83642
- 基因ID
- 29110
- NCBI登录号
- NP_037386
- UniProt
- Q9UHD2
-
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