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RAPTOR 抗体 (pSer863)

RAPTOR 适用: 人 WB, DB, IHC (p) 宿主: 兔 Polyclonal RB24817-24818 unconjugated
产品编号 ABIN389879
发货至: 中国
  • 抗原 See all RAPTOR 抗体
    RAPTOR
    抗原表位
    • 21
    • 15
    • 15
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer863
    适用
    • 68
    • 45
    • 25
    • 15
    • 1
    宿主
    • 68
    • 3
    克隆类型
    • 68
    • 3
    多克隆
    标记
    • 20
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This RAPTOR antibody is un-conjugated
    应用范围
    • 29
    • 26
    • 26
    • 26
    • 8
    • 8
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    Western Blotting (WB), Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This Raptor Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor.
    克隆位点
    RB24817-24818
    亚型
    Ig Fraction
  • 应用备注
    WB: 1:500. IHC-P: 1:100. DB: 1:500
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Cully, Genevet, Warne, Treins, Liu, Bastien, Baum, Tapon, Leevers, Downward: "A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1." in: Molecular and cellular biology, Vol. 30, Issue 2, pp. 481-95, (2009) (PubMed).

  • 抗原
    RAPTOR
    别名
    Raptor (RAPTOR 产品)
    别名
    KOG1 antibody, Mip1 antibody, 4932417H02Rik antibody, Rap antibody, Raptor antibody, mKIAA1303 antibody, RGD1311784 antibody, regulatory associated protein of MTOR complex 1 antibody, regulatory associated protein of MTOR, complex 1 antibody, RPTOR antibody, Rptor antibody
    背景
    Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.
    分子量
    149038
    基因ID
    57521
    NCBI登录号
    NP_065812
    UniProt
    Q8N122
    途径
    Warburg Effect
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