SMAD3 抗体 (pSer208)
(1 reference)-
- 抗原 See all SMAD3 抗体
- SMAD3 (SMAD, Mothers Against DPP Homolog 3 (SMAD3))
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抗原表位
- pSer208
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SMAD3 antibody is un-conjugated
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应用范围
- Immunofluorescence (IF), Dot Blot (DB)
- 预测反应
- C, M, Pig, Rat
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This SMAD3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S208 of human SMAD3.
- 克隆位点
- RB31592-RB31594
- 亚型
- Ig Fraction
- Top Product
- Discover our top product SMAD3 Primary Antibody
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anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 417-425), (pSer423), (pSer425) antibody
SMAD3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 120-221) antibodySMAD3 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 7F3 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 1-230) antibodySMAD3 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 120-221) antibodySMAD3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C12 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 120-221) antibodySMAD3 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2C12 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 1-110) antibodySMAD3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C11 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) antibodySMAD3 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS, IF (cc) 宿主: 兔 Monoclonal 3D1 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 231-425) antibodySMAD3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (C-Term) antibodySMAD3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) antibodyKO Validated SMAD3 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
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- 应用备注
- IF: 1:200. IF: 1:10~50. DB: 1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid freeze-thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
- 有效期
- 6 months
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: "Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-?-mediated growth inhibition." in: Pigment cell & melanoma research, Vol. 24, Issue 3, pp. 512-24, (2011) (PubMed).
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: "Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-?-mediated growth inhibition." in: Pigment cell & melanoma research, Vol. 24, Issue 3, pp. 512-24, (2011) (PubMed).
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- 抗原
- SMAD3 (SMAD, Mothers Against DPP Homolog 3 (SMAD3))
- 别名
- SMAD3 (SMAD3 产品)
- 别名
- HSPC193 antibody, HsT17436 antibody, JV15-2 antibody, LDS1C antibody, LDS3 antibody, MADH3 antibody, madh3 antibody, madh3a antibody, smad3 antibody, wu:fa99e03 antibody, XSmad3 antibody, XenMLP antibody, Xmad3 antibody, madh3-A antibody, Madh3 antibody, AU022421 antibody, Smad 3 antibody, mad3 antibody, madh3b antibody, zgc:92234 antibody, SMAD family member 3 antibody, SMAD family member 3a antibody, SMAD family member 3 L homeolog antibody, SMAD family member 3b antibody, SMAD3 antibody, smad3a antibody, smad3.L antibody, Smad3 antibody, smad3b antibody
- 背景
- SMAD3, a receptor regulated SMAD (R-SMAD) is a transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is estimated to account for at least 80 % of all TGF-beta-mediated response. Activated type I receptor phosphorylates receptor-activated SMADS (RSMADS) at their c-terminal two extreme serines in the SSXS motif. The phosphorylated R-SMAD translocate into nucleus, where they regulate transcription of target genes. SMAD3 signal transduction appears to be important in the rgulation of muscle-specific genes. Loss of SMAD3 is a feature of pediatric T-cell lymphoblastic leukemia, while upregulation of SMAD3 may be responsible for TGFB hyperresponsiveness observed in scleroderma.
- 分子量
- 48081
- 基因ID
- 4088
- NCBI登录号
- NP_001138574, NP_001138575, NP_001138576, NP_005893
- UniProt
- P84022
- 途径
- Cell Division Cycle, Chromatin Binding, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Autophagy
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