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Retinoblastoma 1 抗体 (pSer788)

RB1 适用: 人 IHC (p), DB 宿主: 兔 Polyclonal RB7670 unconjugated
产品编号 ABIN389645
发货至: 中国
  • 抗原 See all Retinoblastoma 1 (RB1) 抗体
    Retinoblastoma 1 (RB1)
    抗原表位
    • 31
    • 24
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    • 18
    • 15
    • 11
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    • 9
    • 6
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    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
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    pSer788
    适用
    • 279
    • 113
    • 99
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 252
    • 29
    克隆类型
    • 247
    • 34
    多克隆
    标记
    • 127
    • 17
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    • 16
    • 11
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    • 6
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    • 2
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    • 2
    • 1
    • 1
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    This Retinoblastoma 1 antibody is un-conjugated
    应用范围
    • 206
    • 119
    • 107
    • 80
    • 79
    • 37
    • 30
    • 27
    • 25
    • 20
    • 17
    • 8
    • 8
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    • 2
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)
    特异性
    This Phospho-Rb-S788 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S788 of human Rb.
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This Rb Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S788 of human Rb.
    克隆位点
    RB7670
    亚型
    Ig Fraction
    Top Product
    Discover our top product RB1 Primary Antibody
  • 应用备注
    DB = 1:500, IHC (p) = 1:50-100
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.45 mg/mL
    缓冲液
    PBS with 0.09 % (W/V) sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Iwahori, Hakki, Chou, Kalejta: "Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97." in: The Journal of biological chemistry, Vol. 290, Issue 32, pp. 19666-80, (2015) (PubMed).

  • 抗原
    Retinoblastoma 1 (RB1)
    别名
    Rb (RB1 产品)
    别名
    OSRC antibody, RB antibody, p105-Rb antibody, pRb antibody, pp110 antibody, Rb antibody, Rb-1 antibody, P105-RB antibody, PP110 antibody, RB11 antibody, zgc:154147 antibody, RB transcriptional corepressor 1 antibody, RB transcriptional corepressor like 1 antibody, retinoblastoma 1 antibody, RB1 antibody, RBL1 antibody, Rb1 antibody, rb1 antibody
    背景
    RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
    Synonyms: Retinoblastoma-associated protein, PP110, P105-RB, RB, RB1,
    分子量
    106159 DA
    基因ID
    5925
    UniProt
    P06400
    途径
    Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
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