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CDKN1B 抗体 (pSer10)

Name: CDKN1B 抗体 (pSer10)
SKU: ABIN389614
Availability: OutOfStock

CDKN1B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7323 unconjugated

The anti-Phospho-p27Kip1-S10 Pab (ABIN653138 and ABIN2842714) is used in Western blot to detect Phospho-p27Kip1-S10 in HL60 tissue lysate (CDKN1B 抗体 (pSer10))

Formalin-fixed and paraffin-embedded human skeletal muscle with Phospho-p27Kip1-S10 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (CDKN1B 抗体 (pSer10))

IHC (p)

2 images

(3 references)

产品编号 ABIN389614

发货至: 中国

Datasheet as PDF

抗原 See all CDKN1B 抗体

CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
抗原表位
29

25

20

18

16

16

10

10

9

8

8

8

8

8

7

7

5

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer10
适用
265

122

103

26

6

6

3

3

3

3

2

1

1
人
宿主
230

48

2

1

1
兔
Compatible Secondaries
克隆类型
225

57
多克隆
标记
133

23

17

16

16

14

4

4

4

4

4

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2
This CDKN1B antibody is un-conjugated
应用范围
195

130

67

60

48

41

32

26

19

16

16

11

7

7

3

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

预测反应

Ha, M

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S10 of human p27Kip1.

克隆位点

RB7323

亚型

Ig Fraction

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anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (AA 1-198) antibody
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anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibody
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anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibody
CDKN1B 适用: 人 IF, FACS, IHC (f) 宿主: 小鼠 Monoclonal SX53G8 unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibody
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anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (AA 1-198) antibody
CDKN1B 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibody
CDKN1B 适用: 小鼠 WB, IF, FACS, IHC (f) 宿主: 小鼠 Monoclonal DCS-72-F6 unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (pThr187) antibody
CDKN1B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (AA 1-198) antibody
CDKN1B 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (AA 1-100) antibody
CDKN1B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Fang, Zhang, Dizeyi, Chen, Wang, Swanson, Cai, Balk, Yuan: "Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation." in: The Journal of biological chemistry, Vol. 287, Issue 3, pp. 2090-8, (2012) (PubMed).

Lee, Kim, Kim, Lee: "Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition." in: Biochimica et biophysica acta, Vol. 1823, Issue 2, pp. 514-23, (2012) (PubMed).

Le, Mao, He, Claret, Xia, Ahmed, Hung, Siddik, Bast: "The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells." in: Journal of the National Cancer Institute, Vol. 103, Issue 18, pp. 1403-22, (2011) (PubMed).
抗原

CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

别名

p27Kip1 (CDKN1B 产品)

别名

CDKN4 antibody, KIP1 antibody, MEN1B antibody, MEN4 antibody, P27KIP1 antibody, cdkn1b antibody, sb:cb611 antibody, wu:fb63g10 antibody, wu:fb64g10 antibody, wu:fe18e03 antibody, CDKN1B antibody, Kip1 antibody, p27 antibody, FAM14D antibody, ISG12 antibody, ISG12A antibody, P27 antibody, Cdki1b antibody, AA408329 antibody, AI843786 antibody, p27Kip1 antibody, cdkn1bl antibody, cyclin dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Bb antibody, interferon alpha inducible protein 27 antibody, cyclin-dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Ba antibody, CDKN1B antibody, cdkn1bb antibody, IFI27 antibody, Cdkn1b antibody, cdkn1ba antibody

背景

P27Kip1 is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

分子量

22073

基因ID

1027

NCBI登录号

NP_004055

UniProt

P46527

途径

Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy