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E2F1 抗体 (pSer337)

E2F1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7692 unconjugated
产品编号 ABIN389553
发货至: 中国
  • 抗原 See all E2F1 抗体
    E2F1 (E2F Transcription Factor 1 (E2F1))
    抗原表位
    • 25
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    • 15
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    pSer337
    适用
    • 187
    • 89
    • 45
    • 6
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    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
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    宿主
    • 190
    • 12
    • 2
    克隆类型
    • 180
    • 24
    多克隆
    标记
    • 90
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    • 5
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    This E2F1 antibody is un-conjugated
    应用范围
    • 175
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    • 48
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This E2F1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S337 of human E2F1.
    克隆位点
    RB7692
    亚型
    Ig Fraction
    Top Product
    Discover our top product E2F1 Primary Antibody
  • 应用备注
    WB: 1:500. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    E2F1 (E2F Transcription Factor 1 (E2F1))
    别名
    E2F1 (E2F1 产品)
    背景
    E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
    分子量
    46920
    基因ID
    1869
    NCBI登录号
    NP_005216
    UniProt
    Q01094
    途径
    p53 Pathway, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy
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