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Cyclin D1 抗体 (AA 68-97)

Name: Cyclin D1 抗体 (AA 68-97)
SKU: ABIN389146
Availability: OutOfStock

CCND1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB8066 unconjugated

Western blot analysis of anti-Cyclin D1 Antibody (S90) (ABIN389146 and ABIN2850438) in mouse lung lysates (35 μg/lane). (Cyclin D1 抗体 (AA 68-97))

IHC (p)

Confocal immunofluorescent analysis of Cyclin D1 Antibody (S90) (ABIN389146 and ABIN2850438) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Cyclin D1 抗体 (AA 68-97))

All lanes : Anti-Cyclin D1 Antibody (S90) at 1:2000 dilution Lane 1: MCF-7 whole cell lysate Lane 2: A431 whole cell lysate Lysates/proteins at 20 μg per lane. (Cyclin D1 抗体 (AA 68-97))

All lanes : Anti-Cyclin D1 Antibody (S90) at 1:2000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: MCF-7 whole cell lysate Lysates/proteins at 20 μg per lane. (Cyclin D1 抗体 (AA 68-97))

5 images

(1 reference)

产品编号 ABIN389146

发货至: 中国

Datasheet as PDF

抗原 See all Cyclin D1 (CCND1) 抗体

Cyclin D1 (CCND1)
抗原表位
22

21

16

16

12

11

9

9

8

7

7

7

6

6

5

5

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 68-97
适用
233

123

120

40

20

18

16

12

10

9

3

3

3

3

3

2

2

1

1

1

1

1

1
人, 小鼠
宿主
202

53

1
兔
Compatible Secondaries
克隆类型
192

62
多克隆
标记
116

25

20

9

7

5

5

5

5

5

5

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1
This Cyclin D1 antibody is un-conjugated
应用范围
193

87

64

61

40

28

28

27

22

19

19

11

6

5

3

2

2

2

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

预测反应

B

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This Cyclin D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-97 amino acids from human Cyclin D1.

克隆位点

RB8066

亚型

Ig Fraction

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anti-Cyclin D1 (CCND1) (AA 68-97) antibody
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CCND1 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, FACS, IF, StM 宿主: 小鼠 Monoclonal DCS-6 unconjugated

anti-Cyclin D1 (CCND1) (AA 1-233) antibody
CCND1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. WB: 1:2000. WB: 1:2000. IHC-P: 1:25

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Chang, Nam, Kook, Kim, Liu, Yao, Jung, Lemos, Seo, Park, Gim, Hong, Huh, Kim, Tan, Liu, Powis, Park, Liang, Kim: "HNF4? is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer." in: Gut, (2014) (PubMed).
抗原

Cyclin D1 (CCND1)

别名

Cyclin D1 (CCND1 产品)

别名

BCL1 antibody, D11S287E antibody, PRAD1 antibody, U21B31 antibody, AI327039 antibody, CycD1 antibody, Cyl-1 antibody, bcl-1 antibody, cD1 antibody, cb161 antibody, cycd1 antibody, etID37810.7 antibody, fb52e01 antibody, fc45c08 antibody, fc83a12 antibody, id:ibd1198 antibody, wu:fb52e01 antibody, wu:fc45c08 antibody, wu:fc83a12 antibody, ccnd1b antibody, prad1 antibody, ccnd1 antibody, ccnd1a antibody, bcl1 antibody, d11s287e antibody, u21b31 antibody, CCND1 antibody, cyclin D1 antibody, cyclin D1 S homeolog antibody, cyclin D1 L homeolog antibody, CCND1 antibody, Ccnd1 antibody, ccnd1 antibody, ccnd1.S antibody, ccnd1.L antibody

背景

CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. It has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

分子量

33729

基因ID

595

NCBI登录号

NP_444284

UniProt

P24385

途径

PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling