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PAPSS1 抗体 (C-Term)

PAPSS1 适用: 人 WB 宿主: 兔 Polyclonal RB5109 unconjugated
产品编号 ABIN389138
发货至: 中国
  • 抗原 See all PAPSS1 抗体
    PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))
    抗原表位
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 592-624, C-Term
    适用
    • 25
    • 3
    • 2
    宿主
    • 22
    • 3
    克隆类型
    • 23
    • 2
    多克隆
    标记
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PAPSS1 antibody is un-conjugated
    应用范围
    • 16
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-624 amino acids from the C-terminal region of human PAPSS1.
    克隆位点
    RB5109
    亚型
    Ig Fraction
    Top Product
    Discover our top product PAPSS1 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Bergelin, Blom, Heikkilä, Löf, Alam, Balthasar, Slotte, Hinkkanen, Törnquist: "Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2." in: Endocrinology, Vol. 150, Issue 5, pp. 2055-63, (2009) (PubMed).

  • 抗原
    PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))
    别名
    PAPSS1 (PAPSS1 产品)
    别名
    ATPSK1 antibody, PAPSS antibody, SK1 antibody, AI325286 antibody, Asapk antibody, papss1 antibody, MGC82588 antibody, atpsk1 antibody, papss antibody, sk1 antibody, PAPSS1 antibody, wu:fc43e12 antibody, zgc:194984 antibody, zgc:194985 antibody, CG8363 antibody, DmPAPSS antibody, Dmel\\CG8363 antibody, PAPS antibody, Paps antibody, l(3)76BDn antibody, paps antibody, 3'-phosphoadenosine 5'-phosphosulfate synthase 1 antibody, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 antibody, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 antibody, PAPS synthetase antibody, PAPSS1 antibody, Papss1 antibody, papss1 antibody, papss1.L antibody, LOC100543301 antibody, LOC100637112 antibody, Papss antibody
    背景
    Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (603005). Bifunctional PAPSS1 is comprised of an N-terminal APS kinase domain, and a C-terminal ATP sulfurylase domain. Full-length protein has significantly less APS kinase activity than the N-terminal fragment, suggesting that the C-terminal domain exerts a regulatory role on the N-terminal APS kinase activity. In humans there are two major isoforms: PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression dominates. The predicted 623-amino acid protein is 98 % identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs.
    分子量
    70833
    基因ID
    9061
    NCBI登录号
    NP_005434
    UniProt
    O43252
    途径
    Glycosaminoglycan Metabolic Process, Ribonucleoside Biosynthetic Process
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