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PPT1 抗体 (N-Term)

PPT1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB4706 unconjugated
产品编号 ABIN389116
发货至: 中国
  • 抗原 See all PPT1 抗体
    PPT1 (Palmitoyl-Protein Thioesterase 1 (PPT1))
    抗原表位
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 32-63, N-Term
    适用
    • 58
    • 17
    • 10
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 52
    • 8
    克隆类型
    • 54
    • 6
    多克隆
    标记
    • 36
    • 6
    • 5
    • 5
    • 4
    • 4
    This PPT1 antibody is un-conjugated
    应用范围
    • 51
    • 37
    • 25
    • 14
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    预测反应
    B, Pr
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This PPT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-63 amino acids from the N-terminal region of human PPT1.
    克隆位点
    RB4706
    亚型
    Ig Fraction
    Top Product
    Discover our top product PPT1 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    PPT1 (Palmitoyl-Protein Thioesterase 1 (PPT1))
    别名
    PPT1 (PPT1 产品)
    别名
    CLN1 antibody, INCL antibody, PPT antibody, 9530043G02Rik antibody, AA960502 antibody, C77813 antibody, D4Ertd184e antibody, Ppt antibody, wu:fj17f04 antibody, zgc:63969 antibody, PPT-1 antibody, ppt1 antibody, palmitoyl-protein thioesterase 1 antibody, Palmitoyl-protein thioesterase 1 antibody, palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) antibody, palmitoyl-protein thioesterase 1 L homeolog antibody, PPT1 antibody, MGYG_00692 antibody, Ppt1 antibody, ppt-1 antibody, ppt1 antibody, ppt1.L antibody
    背景
    Palmitoyl-protein thioesterase-1 (PPT1) is a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. Mutations in PPT1 have been found to cause the infantile form of neuronal ceroid lipofuscinosis (INCL), and an animal model has been developed.1 The deduced PPT2 protein contains 302 amino acids, including a 27-amino acid leader peptide, a sequence motif characteristic of many thioesterases and lipases, and 5 potential N-linked glycosylation sites.2 PPT2 shares 18 % amino acid identity with PPT1. Northern blot analysis detected a predominant 2.0-kb PPT2 transcript in the human tissues examined, with the highest expression in skeletal muscle, variable amounts of 2.8- and 7.0-kb transcripts were also observed. Recombinant PPT2, like PPT1, possesses thioesterase activity and localizes to the lysosome. Since PPT2 could not substitute for PPT1 in correcting the metabolic defect in INCL cells and was unable to remove palmitate groups from palmitoylated proteins that are routinely used as substrates for PPT1it has been postulated that PPT2 possesses a different substrate specificity than PPT1.
    分子量
    34193
    基因ID
    5538
    NCBI登录号
    NP_000301, NP_001136076
    UniProt
    P50897
    途径
    SARS-CoV-2 Protein Interactome
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