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BMI1 抗体 (C-Term)

Name: BMI1 抗体 (C-Term)
SKU: ABIN389084
Availability: OutOfStock

BMI1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB02926 unconjugated

Western blot analysis of BMI1 Antibody (C-term) antibody (ABIN389084 and ABIN2839281) in 293 cell line lysates (35 μg/lane). (BMI1 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human skeletal muscle reacted with BMI1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (BMI1 抗体 (C-Term))

IHC (p)

BMI1 Antibody (C-term) (ABIN389084 and ABIN2839281) western blot analysis in K562 cell line lysates (35 μg/lane). (BMI1 抗体 (C-Term))

3 images

(3 references)

产品编号 ABIN389084

发货至: 中国

Datasheet as PDF

抗原 See all BMI1 抗体

BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))
抗原表位
13

8

6

6

5

5

4

4

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 257-286, C-Term
适用
111

47

27

11

8

7

7

6

5

3

3

3

2

1

1

1

1

1
人
宿主
77

32

6
兔
Compatible Secondaries
克隆类型
80

35
多克隆
标记
75

9

9

6

5

5

1

1

1

1

1

1
This BMI1 antibody is un-conjugated
应用范围
91

51

43

20

12

12

11

6

3

3

3

3

2

2

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

预测反应

B, C, M

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This BMI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human BMI1.

克隆位点

RB02926

亚型

Ig Fraction

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anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibody
BMI1 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 3E3 unconjugated

anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibody
BMI1 适用: 人, 小鼠 WB, IHC, IF, StM 宿主: 小鼠 Monoclonal BMI1-2823 unconjugated

anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 120-326) antibody
BMI1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibody
BMI1 适用: 人, 小鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB22858 unconjugated

anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibody
BMI1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal BMI1-2689 unconjugated

anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 1-326) antibody
BMI1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E10-1C5 unconjugated

anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibody
BMI1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal BMI1-2690 unconjugated

anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 257-286) antibody
BMI1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 61-160) antibody
BMI1 适用: 人 WB, ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 1-247) antibody
BMI1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Wang, Venugopal, Manoranjan, McFarlane, OFarrell, Nolte, Gunnarsson, Hollenberg, Kwiecien, Northcott, Taylor, Hawkins, Singh: "Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells." in: Oncogene, Vol. 31, Issue 2, pp. 187-99, (2012) (PubMed).

Lewis, Segditsas, Deheragoda, Pollard, Jeffery, Nye, Lockstone, Davis, Clark, Stamp, Poulsom, Wright, Tomlinson: "Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5." in: Gut, Vol. 59, Issue 12, pp. 1680-6, (2010) (PubMed).

Sangiorgi, Capecchi: "Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 17, pp. 7101-6, (2009) (PubMed).
抗原

BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

别名

BMI1 (BMI1 产品)

别名

FLVI2/BMI1 antibody, PCGF4 antibody, RNF51 antibody, AW546694 antibody, Bmi-1 antibody, Pcgf4 antibody, bmi1 antibody, pcgf4 antibody, psc1 antibody, wu:fb17g03 antibody, wu:fd18f06 antibody, BMI-1 antibody, pcgf4b antibody, bmi-1 antibody, bmi1-a antibody, bmi1-b antibody, bmi1b antibody, rnf51 antibody, xbmi-1 antibody, BMI1 proto-oncogene, polycomb ring finger antibody, BMI1 polycomb ring finger oncogene antibody, Bmi1 polycomb ring finger oncogene antibody, bmi1 polycomb ring finger oncogene 1a antibody, bmi1 polycomb ring finger oncogene 1b antibody, BMI1 proto-oncogene, polycomb ring finger L homeolog antibody, BMI1 antibody, LOC100230513 antibody, Bmi1 antibody, bmi1a antibody, bmi1b antibody, bmi1.L antibody

背景

BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.

分子量

36949

基因ID

648

NCBI登录号

NP_001190991, NP_005171

UniProt

P35226

途径

Cell Division Cycle, Autophagy