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Androgen Receptor 抗体 (AA 365-392)

AR 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2579 unconjugated
产品编号 ABIN389077
发货至: 中国
  • 抗原 See all Androgen Receptor (AR) 抗体
    Androgen Receptor (AR)
    抗原表位
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    AA 365-392
    适用
    • 309
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    人, 小鼠
    宿主
    • 257
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    克隆类型
    • 248
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    多克隆
    标记
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    This Androgen Receptor antibody is un-conjugated
    应用范围
    • 183
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    Pr, Pig
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This Androgen Receptor (ANDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor (ANDR).
    克隆位点
    RB2579
    亚型
    Ig Fraction
    Top Product
    Discover our top product AR Primary Antibody
  • 应用备注
    WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    Androgen Receptor (AR)
    别名
    Androgen Receptor (ANDR) (AR 产品)
    别名
    AIS antibody, DHTR antibody, HUMARA antibody, HYSP1 antibody, KD antibody, NR3C4 antibody, SBMA antibody, SMAX1 antibody, TFM antibody, AW320017 antibody, Tfm antibody, Andr antibody, AR antibody, androgen receptor antibody, AR antibody, Ar antibody, ar antibody
    背景
    Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor, sumoylation of ANDR represses androgen receptor dependent transcription.
    分子量
    99188
    基因ID
    367
    NCBI登录号
    NP_000035, NP_001011645
    UniProt
    P10275
    途径
    Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
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