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AGL 抗体 (C-Term)

AGL 适用: 人 WB, IF 宿主: 兔 Polyclonal RB4978 unconjugated
产品编号 ABIN389030
发货至: 中国
  • 抗原 See all AGL 抗体
    AGL (Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL))
    抗原表位
    • 7
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 1479-1510, C-Term
    适用
    • 33
    • 1
    宿主
    • 31
    • 2
    克隆类型
    • 33
    多克隆
    标记
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AGL antibody is un-conjugated
    应用范围
    • 18
    • 17
    • 16
    • 10
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This AGL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1479-1510 amino acids from the C-terminal region of human AGL.
    克隆位点
    RB4978
    亚型
    Ig Fraction
  • 应用备注
    IF: 1:10~50. IF: 1:10~50. WB: 1:1000. WB: 1:8000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Guin, Ru, Agarwal, Ritterson Lew, Owens, Comi, Theodorescu: "Loss of glycogen debranching enzyme AGL drives bladder tumor growth via induction of hyaluronic acid synthesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, (2015) (PubMed).

    Liu, Zeng, Ma, Baba, Zheng, Liu, Wang: "Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylase." in: Molecular neurobiology, Vol. 49, Issue 2, pp. 645-57, (2014) (PubMed).

    Zhu, Shen, Zhu, Coorey, Nguyen, Barthelmes, Gillies: "Anti-retinal antibodies in patients with macular telangiectasia type 2." in: Investigative ophthalmology & visual science, Vol. 54, Issue 8, pp. 5675-83, (2013) (PubMed).

    DePaoli-Roach, Tagliabracci, Segvich, Meyer, Irimia, Roach: "Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25372-81, (2010) (PubMed).

    Parker, Kong, Walsh, Salajegheh, Moghadaszadeh, Amato, Nazareno, Lin, Krastins, Sarracino, Beggs, Pinkus, Greenberg: "Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis." in: Muscle & nerve, Vol. 39, Issue 6, pp. 739-53, (2009) (PubMed).

    Cheng, Zhang, Gentry, Worby, Dixon, Saltiel: "A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease." in: Genes & development, Vol. 21, Issue 19, pp. 2399-409, (2007) (PubMed).

  • 抗原
    AGL (Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL))
    别名
    AGL (AGL 产品)
    别名
    DDBDRAFT_0219237 antibody, DDBDRAFT_0234114 antibody, DDB_0219237 antibody, DDB_0234114 antibody, GDE antibody, 1110061O17Rik antibody, 9430004C13Rik antibody, 9630046L06Rik antibody, AI850929 antibody, C77197 antibody, amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase antibody, glycogen debranching enzyme antibody, glycogen debranching protein antibody, amylo-1,6-glucosidase, 4-alpha-glucanotransferase antibody, AGL antibody, agl antibody, MMAH_RS03870 antibody, Agl antibody
    背景
    AGL is a glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in the AGL gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing.
    分子量
    174764
    基因ID
    178
    NCBI登录号
    NP_000019, NP_000633, NP_000634, NP_000635, NP_000636, NP_000637
    UniProt
    P35573
    途径
    Cellular Glucan Metabolic Process
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