Ataxin 3 抗体 (N-Term)
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- 抗原 See all Ataxin 3 (ATXN3) 抗体
- Ataxin 3 (ATXN3)
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抗原表位
- AA 29-59, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Ataxin 3 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This Ataxin3 (MJD) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human Ataxin3 (MJD).
- 克隆位点
- RB4606
- 亚型
- Ig Fraction
- Top Product
- Discover our top product ATXN3 Primary Antibody
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- 应用备注
- IHC-P: 1:50~100. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- Ataxin 3 (ATXN3)
- 别名
- Ataxin3 (MJD) (ATXN3 产品)
- 背景
- Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
- 分子量
- 41250
- 基因ID
- 4287
- NCBI登录号
- NP_001121168, NP_001158252, NP_004984, NP_109376
- UniProt
- P54252
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