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USP33 抗体 (C-Term)

USP33 适用: 人 WB 宿主: 兔 Polyclonal RB4423-4424 unconjugated
产品编号 ABIN388945
发货至: 中国
  • 抗原 See all USP33 抗体
    USP33 (Ubiquitin Specific Peptidase 33 (USP33))
    抗原表位
    • 15
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 799-829, C-Term
    适用
    • 38
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    宿主
    • 36
    • 2
    克隆类型
    • 36
    • 2
    多克隆
    标记
    • 20
    • 4
    • 4
    • 4
    • 3
    • 3
    This USP33 antibody is un-conjugated
    应用范围
    • 24
    • 21
    • 19
    • 9
    • 6
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB)
    预测反应
    B
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This VDU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 799-829 amino acids from the C-terminal region of human VDU1.
    克隆位点
    RB4423-4424
    亚型
    Ig Fraction
    Top Product
    Discover our top product USP33 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    USP33 (Ubiquitin Specific Peptidase 33 (USP33))
    别名
    VDU1 (USP33 产品)
    别名
    USP33 antibody, VDU1 antibody, 9830169D19Rik antibody, AA409780 antibody, Vdu1 antibody, zgc:77308 antibody, ubiquitin specific peptidase 33 antibody, universal stress protein UspA antibody, Usp33 antibody, USP33 antibody, RR_RS17870 antibody, usp33 antibody
    背景
    Type 2 iodothyronine deiodinase (D2) is an integral membrane selenoenzyme that stimulates the pro-hormone thyroxine (T4) and supplies the majority of the 3,5,3?-triiodothyronine (T3) essential for brain development.1 T4 catalysis accelerates selective conjugation to ubiquitin and thereby renders D2 inactive, a posttranslational feedback mechanism used to maintain acceptable T3 levels.2,3 Ub-D2 was the first recognized substrate for von Hippel?Lindau protein?interacting (pVHL-interacting) deubiquitinating enzyme-1 (VDU1).4 VDU proteins colocalize with D2 in the endoplasmic reticulum, and their coexpression provides D2 resistance to degradation. VDU1 expression is substantially upregulated in brown adipocytes by norepinephrine or cold exposure, further amplifying D2 activity. VDU1 and VDU2 are coexpressed with D2 in many human tissues, including brain, heart, and skeletal muscle, suggesting potential roles in neurological development, cardiac function, and energy management, in addition to thermal homeostasis.VDU1- or VDU2-catalyzed deubiquitination recycles inactive Ub-D2 to its active deubiquitinated form, circumventing the proteasomal degradation pathway. Thus, Ub-D2 can be either reactivated or degraded, with the balance between these two processes influenced by VDU activity.VDU1-catalyzed D2 deubiquitination may be an important participant in the adaptive mechanism that regulates thyroid hormone action. The reversible ubiquitination-dependent mechanism regulating D2 activity permits highly responsive control of thyroid hormone activation.5,6
    分子量
    106727
    基因ID
    23032
    NCBI登录号
    NP_055832, NP_963918, NP_963920
    UniProt
    Q8TEY7
    途径
    Regulation of G-Protein Coupled Receptor Protein Signaling
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